表没食子儿茶素没食子酸酯分子修饰及抗癌研究进展  

Progress in Molecular Modification and Anticancer Activity of(–)-Epigallocatechin-3-gallate(EGCG)

作　　者：刘飞[1] 熊政委[2] 李春华[1] 张娟[1] 王小萍[1] 唐晓波[1] 王云[1] 

机构地区：[1]四川省农业科学院茶叶研究所,四川成都610066 [2]重庆第二师范学院生物与化学工程系,重庆400067

出　　处：《食品科学》2015年第23期321-328,共8页Food Science

基　　金：国家现代农业(茶)产业技术体系建设专项(CARS-23);国家现代农业产业技术体系四川省茶叶技术创新团队建设专项

摘　　要：表没食子儿茶素没食子酸酯((–)-epigallocatechin-3-gallate,EGCG)是茶叶中的一类重要儿茶素,在体内外实验中被证实具有广泛的抗癌活性。研究发现,其抗癌机理包含诱导细胞凋亡、抗血管生成、调控细胞周期、阻滞细胞转移、协同抗癌等,但由于多羟基的化学结构使其在中性或碱性介质中极不稳定,最终导致其生物活性利用率降低,限制了临床应用范围。已有研究表明,分子修饰能显著改善EGCG分子活性,增强其稳定性,并使其表现出较强的抗癌活性。本文首先概述EGCG分子修饰的方法,然后对EGCG及其衍生物的抗癌实例和作用机理进行归纳总结。（–）-Epigallocatechin-3-gallate（EGCG）, one of the important catechins in tea, has been demonstrated to have anticancer activity both in vitro and in vivo. The anticancer mechanism has been confirmed to be associated with cell apoptosis, resistance to angiogenesis, regulation of cell cycles, retardation of cell transfer, and collaborative anticancer effects. Unfortunately, EGCG has limited clinical applications due to its unstable characteristics in neutral or alkaline environment, which stems from its ＂polyhydroxyl＂ structure. Previous studies have demonstrated that the anticancer activity and stability of EGCG can be remarkably improved by molecular modification. The review summarizes the methods used for molecular modification of EGCG and the anticancer effects and mechanisms of EGCG and its derivatives.

关 键 词：表没食子儿茶素没食子酸酯 分子修饰 衍生物 抗癌机理 纳米材料 

分 类 号：TS272.2[农业科学—茶叶生产加工] TS272.4[轻工技术与工程—农产品加工及贮藏工程]