Studies on Cardiac Cytoarchitectonic and Biochemical Indices in Pregnant Streptozotocin-lnduced Diabetic Rats Treated with Gliclazide and Insulin  

作　　者：Olojede Samuel Oluwaseun Lawal Sodiq Kolawole Medubi Leke Jacob Adekoya Abimbola Julius Esubi Juan Uche Dauda Feyikemi Funmilayo Buhari Muhammed Olanrewaju Osinubi Abraham Adewale 

机构地区：[1]Department of Anatomy, College of Medicine of the University of Lagos, Lagos100254, Nigeria [2]Department of Anatomy, St. Francis University, College of Health and Allied Sciences, Ifakara-Morogoro 67501, Tanzania [3]Department of Human Anatomy, Western Campus, Kampala International University, Ishaka-Bushenyi 25647, Uganda

出　　处：《Journal of Pharmacy and Pharmacology》2018年第1期38-51,共14页药剂与药理学（英文版）

摘　　要：Introduction： GDM （gestational diabetes mellitus） is a common complication of pregnancy, and prevalence has become alarming. Insulin remains the cornerstone in management of diabetes mellitus but oral agents have been increasingly viewed as potential alternatives to insulin because it＇s economically low in cost, easier to administer and affordable to monitor compare to insulin. Aim： This study aimed to determine the effects of Gliclazide on the heart cytoarchitectonic and some biochemical indices of pregnant STZ （streptozotocin）-induced diabetic rats compare with insulin. Methods： Twenty （20） pregnant Sprague Dawley rats weighing between 130 g and 150 g were used for the experiments. The rats were divided into four （4） groups： Group 1 （Non-diabetic）, Group 2 （Diabetic）, Group 3 （Diabetic ＋ Gliclazide） and Group 4 （Diabetic ＋ Insulin）. The glucose levels and body weights were monitoring daily. The experimental rats were sacrificed on the 19th on gestational period, blood samples and organs were collected for biochemical and histo-morphological examinations. Results： Gliclazide group rats showed significant increase in body weight compared with diabetic group Q9 〈 0.05）. The blood glucose level of rats in gliclazide group was significantly reduced compared with other groups. There was significant increase in reduced GSH （glutathione） of gliclazide and insulin groups compared with diabetic group. MDA （malondialdehyde） and CAT （catalase） levels activities were significantly increase in diabetic group compared with other groups. Hormonal profiles and hematological parameters are significantly increased in gliclazide, and insulin group compared with diabetic group. There were distortions in the structural organization of heart of diabetic group while gliclazide and insulin groups showed remarkable improvements of the degenerative changes of the myocardium. Conclusions： Gliclazide glycemic control has shown beneficial effects on the cardiomyocytes damage

关 键 词：GLICLAZIDE Gestational diabetes mellitus INSULIN CARDIOMYOCYTES oxidative stress. 

分 类 号：R0[医药卫生]