Scopariusols L–T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius  

作　　者：JIANG Hua-Yi LI Xiao-Nian SUN Han-Dong ZHANG Hong-Bin PUNO Pema-Tenzin 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resources,Ministry of Education,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China [2]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy ofSciences,Kunming 650201,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Natural Medicines》2018年第6期456-464,共9页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21322204);the NSFC-Joint Foundation of Yunnan Province(No.U1302223)

摘　　要：Nine new ent-kaurane diterpenoids, named scopariusols L–T(1–9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 0.6 μmol·L-1.Nine new ent-kaurane diterpenoids, named scopariusols L-T（1-9）, were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines（HL-60, SMMC-7721, A-549, MCF-7, and SW-480）, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 0.6 μmol·L-1.

关 键 词：ISODON scoparius ENT-KAURANE DITERPENOIDS X-ray diffraction CYTOTOXICITY ANTI-INFLAMMATORY activity 

分 类 号：R284[医药卫生—中药学]