纳豆粉与红曲粉组合对高脂小鼠的降脂效果  

Lipid-lowering Effect of Natto and Monascus Mixture in Hyperlipidemic Mice

作　　者：王素贞[1] 黄占旺[1] 黄永平[1] 陈佳妮[1] WANG Su-zhen;HUANG Zhan-wang;HUANG Yong-ping;CHEN Jia-ni(Jiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, Chin)

机构地区：[1]江西农业大学食品科学与工程学院,江西省天然产物与功能食品重点实验室,江西南昌330045

出　　处：《食品工业科技》2018年第14期292-296,305,共6页Science and Technology of Food Industry

基　　金：国家自然科学基金(31160337)

摘　　要：以纳豆冻干粉、红曲粉的复合物为原料,采用脂肪乳剂灌胃雌性昆明小鼠建立高脂模型。按小鼠体重水平均衡分为8组,其中7组以高脂小鼠为模型,另1组以灌胃生理盐水小鼠为对照。不同浓度组合的复合物(200 mg/m L纳豆粉、100 mg/m L红曲粉、100 mg/m L纳豆粉+25 mg/m L红曲粉、100 mg/m L纳豆粉+100 mg/m L红曲粉、200 mg/m L纳豆粉+25 mg/m L红曲粉、200 mg/m L纳豆粉+100 mg/m L红曲粉)按照剂量进行分组灌胃,灌胃期间观察小鼠的形态和体重变化,灌胃期结束后测定小鼠的器官指数肝体比、脂肪系数、血清脂质水平变化和肝脏中胆固醇(TC)与甘油三酯(TG)含量。结果表明:高剂量的纳豆粉与红曲粉复合物(200 mg/m L纳豆粉+100 mg/m L红曲粉)能够极显著降低高脂小鼠血清TC水平(p<0.01),显著降低高脂小鼠血清TG水平(p<0.05),极显著提高高密度脂蛋白-胆固醇(HDL-C)水平(p<0.01),显著降低高脂小鼠肝脏TC、TG水平(p<0.05),发挥降脂作用。因此纳豆粉与红曲粉组合具有辅助降低小鼠血脂作用,从而促进小鼠降脂活性功能的效果。Natto lyophilized powder and red yeast rice powder was the raw material.Female Kunming mice were inoculated with fat emulsion to establish a model of hyperlipidemia.According to the level of body weight,mice were equally divided into eight groups,seven of which were high-fat mice and the other group were normal mice. Different concentrations of the compound（ 200 mg/mL natto lyophilized powder,100 mg/mL red yeast rice powder,100 mg/mL natto lyophilized powder ＋ 25 mg/mL red yeast rice powder,100 mg/mL natto lyophilized powder ＋ 100 mg/mL red yeast rice powder,200 mg/mL natto lyophilized powder ＋ 25 mg/mL red yeast rice powder,200 mg/mL natto lyophilized powder ＋ 100 mg/mL red yeast rice powder） which formulated into different doses were gavage according to the situation of experimental groups.Morphological and weight changes in mice were observed during the gavage period.After the gavage period,organ index in mice including liver to body ratio and fat coefficient,serumLipid levels and liver cholesterol（ TC） and triglyceride（ TG） content were determined. The results showed that the high dose of compound（ 200 mg/mL natto lyophilized powder ＋ 100 mg/mL red yeast rice powder） could significantly reduce the level of TC（ p〈0.01） and TG in serum（ p〈0.05）,increase the level of high density lipoprotein-cholesterol（ HDL-C）（ p〈0.01）,and reduce the level of TC and TG in mice liver significantly（ p〈0.05）,and play a lipicl-lowering effect.Therefore,the compound of natto lyophilized powder and red yeast rice powder could play a synergistic effect in reducing lipid level and jointly promote lipid-lowering activity in mice.

关 键 词：纳豆冻干粉 红曲粉 脂肪乳剂 脂质水平 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]