MicroRNAs of microglia： wrestling with central nervous system disease  

作　　者：Xiao-Hua Wang Tian-Long Wang 

机构地区：[1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Institute of Geriatrics, Beijing, China [3]National Clinical Research Center for Geriatric Disorders, Beijing, China

出　　处：《Neural Regeneration Research》2018年第12期2067-2072,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81401084(to XHW);Beijing Municipal Administration of Hospital Ascent Plan,No.DFL20150802(to TLW);Beijing 215 High Level Healthcare Talent Plan Academic Leader,No.008-0027(to TLW);Beijing Municipal Commission of Health and Family Planning,No.PXM2017_026283_000002(to TLW);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding,No.ZYLX201706(to TLW)

摘　　要：Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroinflammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against central nervous system disease via multiple functional microRNAs.Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroinflammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against central nervous system disease via multiple functional microRNAs.

关 键 词：MICROGLIA NEURODEGENERATION central nervous system disease MICRORNAS activation polarization AUTOPHAGY neural regeneration 

分 类 号：R741[医药卫生—神经病学与精神病学]