几种不同钙化合物对大鼠铝、铅代谢的影响  

INFLUENCE OF VARIOUS CALCIUM COMPOUNDS ON ALUMINIUM AND LEAD METABOLISM IN RATS

作　　者：王劲[1] 柳启沛[1] 黄宗枝[2] 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生学教研室,上海200032 [2]中国科学院原子核研究所

出　　处：《营养学报》2002年第3期297-300,共4页Acta Nutrimenta Sinica

基　　金：研究生课题经费及自筹

摘　　要：目的 :　观察不同钙化合物对大鼠铝、铅代谢的影响。方法 :　将幼年 Sprague-Dawley大鼠 3 0只 (雌雄性各半 ) ,分成柠檬酸钙 +铝 +铅组、醋酸钙 +铝 +铅组和碳酸钙 +铝 +铅组等三组。各组动物分别用不同形式的钙化合物通过灌胃给予等剂量钙元素 ,共四周。实验结束后 ,用电感耦合等离子体原子发射光谱法 (ICP-AES)分别测定全血、肝、肾、股骨和大脑中铝和铅的含量。结果 :　 (1 )大鼠摄入醋酸钙和柠檬酸钙后对铅的表观吸收率高于碳酸钙组的大鼠。 (2 )摄入柠檬酸钙和醋酸钙的大鼠的组织中铝和铅水平高于摄入碳酸钙的大鼠 ,且大脑和骨骼中尤为明显。结论 :　 (1 )长期摄入柠檬酸钙和醋酸钙有增加铅吸收的危险 ,并可使铅和铝蓄积在骨骼和大脑。(2 )碳酸钙可能比柠檬酸钙和醋酸钙更有利于铝从肾排出。Objective: To observe the influence of different calcium compounds on aluminium and lead metabolism in young rats. Methods: Thirty young rats, half male and half female, were divided into three groups: Ca citrate+Al+Pb group, Ca acetate+Al+Pb group, and Ca carbonate+Al+Pb group. Rats were given the same dose of calcium by gavage of various calcium compounds for 4 w. At the end of experiment, Al and Pb levels in whole blood, liver, kidney, femur and cerebrum were measured by ICP AES. Results: (1) The rats treated with calcium citrate and calcium acetate enhanced lead apparent absorptivity, as compared with calcium carbonate. (2) Elevated aluminium and lead levels were more evident in cerebrum and bone. Conclusion: (1) long term ingestion of Ca acetate and Ca citrate implicates a risk of enhanced Al and Pb absorption and accummulation in the cerebrum and bone.(2) calcium carbonate may be more helpful than calcium acetate and calcium citrate in facilitating Al excretion through kidney.

关 键 词：铝代谢 补钙剂 醋酸钙 柠檬酸钙 碳酸钙 钙化合物 铅代谢 

分 类 号：R151[医药卫生—营养与食品卫生学]