膳食多酚通过法呢醇X受体调节脂质代谢作用研究进展  

Dietary Polyphenols Modulate Lipid Metabolism by Regulating Farnesoid X Receptor: A Review

作　　者：肖娟[1,2] 张瑞芬[2] 温叶杰 黄菲[2] 张名位[2] 孙远明[1] XIAO Juan;ZHANG Ruifen;WEN Yejie;HUANG Fei;ZHANG Mingwei;SUN Yuanming(College of Food Science, South China Agricultural University, Guangzhou 510642, China;Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China)

机构地区：[1]华南农业大学食品学院,广东广州510642 [2]广东省农业科学院蚕业与农产品加工研究所,农业部功能食品重点实验室,广东省农产品加工重点实验室,广东广州510610

出　　处：《食品科学》2017年第7期278-283,共6页Food Science

基　　金：国家自然科学基金青年科学基金项目(31501478);广东省自然科学基金博士启动项目(2014A030310328)

摘　　要：高脂血症是许多慢性疾病的基础病因,由高脂血症引发的心脑血管病等慢性疾病已成为世界性的公共健康问题。法呢醇X受体(farnesoid X receptor,FXR)在胆固醇、甘油三酯等代谢上发挥的重要作用使其有望作为治疗高脂血症及相关疾病的药物靶点。膳食多酚具有良好的生物活性,可以通过调节FXR及其下游脂质代谢相关靶基因的表达从而发挥调节脂质代谢的作用。本文综述了膳食多酚通过FXR调节脂质代谢的研究进展。Hyperlipidemia is an underlying cause of many chronic diseases,and the cardiovascular diseases and other hronic diseases partially caused by hyperlipidemia has become a worldwide public health problem.Farnesoid X receptor FXR)plays a key role in the regulation of cholesterol and triglycerides metabolism.FXR might be a pharmacological arget for the treatment of hyperlipidemia and related diseases.Dietary polyphenols can exert hypolipidemic activity by egulating FXR and its targeted genes.This paper reviews the advances in understanding the mechanism of action of FXR in odulating lipid metabolism and the possible effect of dietary polyphenols in such a bioprocess.

关 键 词：多酚 脂质代谢 法呢醇X受体 

分 类 号：TS201.4[轻工技术与工程—食品科学]