天然产物与microRNA调控代谢综合征的研究进展  

Progress in Research on Natural Products in MicroRNA Regulation for Metabolic Syndrome Improvement

作　　者：郭钦[1] 白洁[1] 何宇轩[1] 唐川惠 操庆国[1,2] 董英[1] GUO Qin;BAI Jie;HE Yuxuan;TANG Chuanhui;CAO Qingguo;DONG Ying(School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China;Institute of Biological Engineering, Jiangsu Polytechnic College of Agriculture and Forestry, Jurong 212000, China)

机构地区：[1]江苏大学食品与生物工程学院,江苏镇江212013 [2]江苏农林职业技术学院生物工程系,江苏句容212000

出　　处：《食品科学》2017年第9期239-247,共9页Food Science

基　　金：国家自然科学基金面上项目(31371760);江苏省高等学校大学生创新项目(201510299072X)

摘　　要：代谢综合征已成为全球性的健康问题。microRNA(miRNA)是一类能够调节基因表达的短单链內源非编码RNA(约22 nt),在转录后水平调节基因表达。miRNA在代谢综合征中发挥重要作用,药食同源的天然产物可以通过调控miRNA的活性和功能,改善糖脂代谢紊乱。本文主要综述miRNA在糖尿病、肥胖等代谢综合征的致病机制中的研究进展,深入分析了药食同源的天然产物对miRNA的调控机制,可为发掘miRNA在代谢综合征预防、诊断、治疗中的潜在价值提供理论依据。The metabolic syndrome has become a global health problem.microRNA(miRNA),a short single-stranded endogenously expressed RNA(approximately22nt),regulates gene expression at the post-transcriptional level.A lot of researches have shown that miRNA plays an important role in metabolic syndromes.Additionally,natural products which can be used as both food and medicine can modulate the activities and functions of miRNA to improve glucose and lipid metabolism disorders.Recent evidence described in this review highlights the significant role of miRNA in metabolic syndromes and how dietary factors may influence metabolic syndromes by modulating the activities and functions of miRNA.

关 键 词：代谢综合征 MICRORNA 天然产物 

分 类 号：TS201.4[轻工技术与工程—食品科学]