Liver as a target of human immunodeficiency virus infection  

作　　者：Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna 

机构地区：[1]Research Service,Veterans Affairs Nebraska-Western Iowa Health Care System [2]Department of Internal Medicine,University of Nebraska Medical Center [3]Department of Pharmacology and Experimental Neuroscience,University of Nebraska Medical Center

出　　处：《World Journal of Gastroenterology》2018年第42期4728-4737,共10页世界胃肠病学杂志（英文版）

基　　金：the Nebraska Research Initiative Grant

摘　　要：Liver injury is a characteristic feature of human immunodeficiency virus(HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy(ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIV-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIV-infection and liver cells are prominently involved in HIV-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIV, clinical evidence of HIVrelated liver damage, interactions between HIV and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression.Liver injury is a characteristic feature of human immunodeficiency virus(HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy(ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIV-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIV-infection and liver cells are prominently involved in HIV-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIV, clinical evidence of HIVrelated liver damage, interactions between HIV and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression.

关 键 词：LIVER cells ANTIRETROVIRAL therapy Apoptosis Inflammation FIBROSIS IMMUNODEFICIENCY VIRUS ALCOHOL 

分 类 号：R57[医药卫生—消化系统]