Focus on the gut-brain axis: multiple sclerosis, the intestinal barrier and the microbiome  

作　　者：Carlos R Camara-Lemarroy Luanne M Metz V Wee Yong 

机构地区：[1]Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary [2]Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary

出　　处：《World Journal of Gastroenterology》2018年第37期4217-4223,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by the Lejoie-Lake Fellowship(to Camara-Lemarroy CR)awarded by the Hotchkiss Brain Institute

摘　　要：The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results.The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Besides being of pathophysiological interest, the brain-gut axis could also open new avenues of therapeutic targets. Modification of the microbiome, the use of probiotics, fecal microbiota transplantation, supplementation with bile acids and intestinal barrier enhancers are all promising candidates. Hopefully, pre-clinical studies and clinical trials will soon yield significant results.

关 键 词：Multiple SCLEROSIS MICROBIOME Intestinal barrier Bile acids Gut-brain AXIS 

分 类 号：R57[医药卫生—消化系统]