Is the determination of ctDNA a scientific “spy” that foresees cancer?  

作　　者：Joana Espiga de Macedo Manuela Machado 

机构地区：[1]Department of Medical Oncology, Centro Hospitalar de Entre Douro e Vouga [2]Department of Medical Oncology, Portuguese Institute of Oncology

出　　处：《World Journal of Respirology》2017年第2期35-38,共4页世界呼吸病学杂志

摘　　要：Since 1948, circulating tumour DNA(ctDNA) was first identified in human blood. ctDNA is in fact DNA shed by tumour cells from all metastatic tumour locations throughout the whole body, and is thrown into the bloodstream and can then be isolated by a standard blood draw. Using this technique scientists can obtain a wide view of tumour heterogeneity, identify different mechanisms of drug resistance, what is its predominance and the clinical rational of precision cancer medicine become a part of our daily practice. Secondly, early detection of cancer may also contribute to global decrease in cancer mortality.Since 1948, circulating tumour DNA(ctDNA) was first identified in human blood. ctDNA is in fact DNA shed by tumour cells from all metastatic tumour locations throughout the whole body, and is thrown into the bloodstream and can then be isolated by a standard blood draw. Using this technique scientists can obtain a wide view of tumour heterogeneity, identify different mechanisms of drug resistance, what is its predominance and the clinical rational of precision cancer medicine become a part of our daily practice. Secondly, early detection of cancer may also contribute to global decrease in cancer mortality.

关 键 词：TUMOUR BIOPSIES Liquid BIOPSIES CIRCULATING TUMOUR DNA Precision CANCER medicine 

分 类 号：R[医药卫生]