Role of leptin in the progression of psoriatic,rheumatoid and osteoarthritis  

作　　者：Jessica Mounessa Iryna Voloshyna Amy D Glass Allison B Reiss 

机构地区：[1]Winthrop Research Institute and Department of Medicine,Winthrop-University Hospital,SUNY Stony Brook School of Medicine

出　　处：《World Journal of Rheumatology》2016年第1期9-15,共7页世界风湿病学杂志

基　　金：Supported by The Elizabeth Daniell Research Fund

摘　　要：Leptin,an adipokine responsible for body weight regulation,may be involved in pathological processesrelated to inflammation in joint disorders including rheumatoid arthritis(RA),osteoarthritis,and psoriatic arthritis(PsA).These arthropathies have been associated with a wide range of systemic and inflammatory con-ditions including cardiovascular disease,obesity,and metabolic syndrome.As a potent mediator of immune responses,leptin has been found in some studies to play a role in these disorders.Furthermore,current potent biologic treatments effectively used in Ps A including ustekinumab(an interleukin 12/23 blocker) and ada-limumab(a tumor necrosis factor-alpha blocker also used in RA) have been found to increase leptin receptor expression in human macrophages.This literature review aims to further investigate the role leptin may play in the disease activity of these arthropathies.Leptin,an adipokine responsible for body weight regulation,may be involved in pathological processesrelated to inflammation in joint disorders including rheumatoid arthritis(RA),osteoarthritis,and psoriatic arthritis(PsA).These arthropathies have been associated with a wide range of systemic and inflammatory con-ditions including cardiovascular disease,obesity,and metabolic syndrome.As a potent mediator of immune responses,leptin has been found in some studies to play a role in these disorders.Furthermore,current potent biologic treatments effectively used in Ps A including ustekinumab(an interleukin 12/23 blocker) and ada-limumab(a tumor necrosis factor-alpha blocker also used in RA) have been found to increase leptin receptor expression in human macrophages.This literature review aims to further investigate the role leptin may play in the disease activity of these arthropathies.

关 键 词：Psoriatic ARTHRITIS RHEUMATOID ARTHRITIS LEPTIN USTEKINUMAB Tumor NECROSIS FACTOR-ALPHA 

分 类 号：R[医药卫生]