Is periprostatic adipose tissue associated with aggressive tumor biology in prostate cancer?  

Is periprostatic adipose tissue associated with aggressive tumor biology in prostate cancer?

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作  者:Philip P Den Hollander Kevin LJ Rademakers Joep GH van Roermund 

机构地区:[1]Department of Urology, Maastricht University Medical Centre,6202 AZ Maastricht, The Netherlands

出  处:《World Journal of Clinical Urology》2014年第3期320-324,共5页世界临床泌尿杂志

摘  要:The prevalence of overweight and obesity and their health-related problems have been increasing.Obesity is increasingly recognized as a risk factor in different types of cancer in humans.The mechanisms supporting the link between obesity and cancer development have not been fully understood.Leptin,a circulating cytokine produced by adipocytes,may influence prostate cancer(PCa)progression in different ways.Body mass index seems to be an unreliable predictor for the development of PCa,but its influence on progression and poor oncological outcomes seems to be clear.Given the fact that abdominal fat is the most metabolically active fat,with different metabolic and paracrine effects,related anthropometric measurements may lead to a better estimation of PCa risk.Metabolically active periprostatic abdominal fat may also play an important role in releasing cytokines and growth factors that may promote tumor cell proliferation or even create a favorable environment for aggressive tumor biology.Different imaging measurements,e.g.,periprostatic adipose tissue(PPAT)thickness,may be significant predictors of PCa.Several genes in the PPAT of obese men have been identified to contribute to chronic immuno-inflammatory responses which eventually lead to cell cycle alterationwith oncological potential.In vitro studies showed the importance of PCa and its interaction with its microenvironment particularly in patients with aggressive PCa.Different types of cytokines,such as interleukin-6,may promote a tumorigenic microenvironment.This article endeavors to review the current literature on the association of PPAT with aggressive tumor biology in PCa.The prevalence of overweight and obesity and their health-related problems have been increasing.Obesity is increasingly recognized as a risk factor in different types of cancer in humans.The mechanisms supporting the link between obesity and cancer development have not been fully understood.Leptin,a circulating cytokine produced by adipocytes,may influence prostate cancer(PCa)progression in different ways.Body mass index seems to be an unreliable predictor for the development of PCa,but its influence on progression and poor oncological outcomes seems to be clear.Given the fact that abdominal fat is the most metabolically active fat,with different metabolic and paracrine effects,related anthropometric measurements may lead to a better estimation of PCa risk.Metabolically active periprostatic abdominal fat may also play an important role in releasing cytokines and growth factors that may promote tumor cell proliferation or even create a favorable environment for aggressive tumor biology.Different imaging measurements,e.g.,periprostatic adipose tissue(PPAT)thickness,may be significant predictors of PCa.Several genes in the PPAT of obese men have been identified to contribute to chronic immuno-inflammatory responses which eventually lead to cell cycle alterationwith oncological potential.In vitro studies showed the importance of PCa and its interaction with its microenvironment particularly in patients with aggressive PCa.Different types of cytokines,such as interleukin-6,may promote a tumorigenic microenvironment.This article endeavors to review the current literature on the association of PPAT with aggressive tumor biology in PCa.

关 键 词:PROSTATE CANCER OBESITY Periprostatic FAT 

分 类 号:R[医药卫生]

 

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