Roles of catecholamine related polymorphisms in hypertension  

作　　者：Oya Orun 

机构地区：[1]Marmara University School of Medicine Biophysics Department

出　　处：《World Journal of Hypertension》2016年第1期41-52,共12页世界高血压杂志

摘　　要：The objective of this review is to summarize current data obtained so far in catecholamine-essential hypertension(EH) relationships on a genetic basis. As the major elements driving the sympathetic system's actions, catecholamines modulate a variety of physiological processes and mutations related to the system. This could generate serious disorders, such as severe mental illnesses, stress-induced disorders, or impairedcontrol of blood pressure or motor pathways. EH is idiopathic, and the genetic basis of its causes and substantial interindividual discrepancies in response to different types of treatments are the focus of interest. Susceptibility to disease or efficacy of treatments are thought to reflect genomic variabilities among individuals. Therefore, outlining the available knowledge in functional genetic polymorphisms linked to EH will make the picture clearer and will help to establish future prospects in the field.The objective of this review is to summarize current data obtained so far in catecholamine-essential hypertension(EH) relationships on a genetic basis. As the major elements driving the sympathetic system's actions, catecholamines modulate a variety of physiological processes and mutations related to the system. This could generate serious disorders, such as severe mental illnesses, stress-induced disorders, or impairedcontrol of blood pressure or motor pathways. EH is idiopathic, and the genetic basis of its causes and substantial interindividual discrepancies in response to different types of treatments are the focus of interest. Susceptibility to disease or efficacy of treatments are thought to reflect genomic variabilities among individuals. Therefore, outlining the available knowledge in functional genetic polymorphisms linked to EH will make the picture clearer and will help to establish future prospects in the field.

关 键 词：Single nucleotide polymorphism CATECHOLAMINE ADRENERGIC RECEPTOR Dopamine RECEPTOR HYPERTENSION EPINEPHRINE NOREPINEPHRINE 

分 类 号：R[医药卫生]