New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum  

作　　者：DING Cai-Feng DAI Zhi YU Hao-Fei ZHAO Xu-Dong LUO Xiao-Dong 

机构地区：[1]Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Science/Key Laboratory of Bioactive Peptides of Yunnan Province,Kunming Institute of Zoology,Kunming 650223,China [3]Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education and Yunnan Province,School of Chemical Science and Technology,Yunnan University,Kunming 650091,China [4]School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University,Kunming 650500,China [5]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Natural Medicines》2019年第9期698-706,共9页中国天然药物（英文版）

基　　金：supported by the Natural Science Foundation of China(U1802281,31770388)

摘　　要：Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.Seven new isoquinoline alkaloids, 9-（2’-formyl-5’, 6’-dimethoxyphenoxy）-1, 2, 3, 10-tetramethoxy dehydroaporphine（1）, 9-（2’-formyl-5’, 6’-dimethoxyphenoxy）-1, 2, 3, 10-tetramethoxy oxoaporphine（2）, 3-methoxy-2’-formyl oxohernandalin（3）,（–）-9-（2’-methoxycarbonyl-5’, 6’-dimethoxyphenoxy）-1, 2, 3, 10-tetramethoxy aporphine（4）,（–）-2’-methoxycarbonyl thaliadin（5）,（–）-9-（2’-methoxyethyl-5’, 6’-dimethoxyphenoxy）-1, 2, 3, 10-tetramethoxy aporphine（6）,（–）-3-methoxy hydroxyhernandalinol（7）, together with six known isoquinoline alkaloids（8–13） were isolated from the roots of Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells（GSC-3# and GSC-18#） with IC50 values ranging from 2.36 to 5.37 μg·mL–1.

关 键 词：THALICTRUM foetidum APORPHINE ALKALOIDS SELECTIVE CYTOTOXICITY GLIOMA stem cells 

分 类 号：R284[医药卫生—中药学]