APORPHINE

作品数：6被引量：11H指数：2
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相关领域：医药卫生更多>>
相关机构：中国科学院上海生命科学研究院更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Asian Pacific Journal of Tropical Biomedicine》《Chinese Chemical Letters》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金更多>>
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Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation被引量：5
《Acta Pharmaceutica Sinica B》2023年第9期3782-3801,共20页Junjie Yang Yue Pan Xiaoshan Zeng Shuwen Liu Zhipeng Chen Kui Cheng 
supported by Foundation National Natural Science Foundation of China(Nos.82073689,82273762);National Key Research and Development Program of China(No.2022YFC2304203);Key Program of National Natural Science Foundation of China(No.82130101);National Natural Science Foundation of Guangdong Province(No.2018B030312010,China);Science and Technology Program of Guangzhou(No.201904010380,China)。
Toll-like receptor 2(TLR2)mediated macrophages regulate the protective immune response to infectious microorganisms,but the aberrant activation of macrophages often leads to pathological inflammation,including tissue ...
关键词：Taspine derivative TLR2 inhibitor MYD88 NF-κB signaling pathway Macrophage polarization Anti-acute inflammatory 
Crebanine N-oxide, a natural aporphine alkaloid isolated from Stephania hainanensis, induces apoptosis and autophagy in human gastric cancer SGC-7901 cells
《Asian Pacific Journal of Tropical Biomedicine》2020年第5期224-231,共8页Zheng-Wen Wang Hao Liu Geng-Tai Ye Zhi-Yong Sheng Yan-Feng Hu Yin-Feng Tan Guo-Xin Li 
supported by the National Natural Science Foundation of China(NO.81760628).
Objective: To investigate the cytotoxic effects and the potential mechanisms of crebanine N-oxide in SGC-7901 gastric adenocarcinoma cells. Methods: The cytotoxicity of crebanine N-oxide was evaluated by 3-(4,5-dimeth...
关键词：Crebanine N-OXIDE Gastric cancer SGC-7901 cells APOPTOSIS AUTOPHAGY 
New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum
《Chinese Journal of Natural Medicines》2019年第9期698-706,共9页DING Cai-Feng DAI Zhi YU Hao-Fei ZHAO Xu-Dong LUO Xiao-Dong 
supported by the Natural Science Foundation of China(U1802281,31770388)
Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxo...
关键词：THALICTRUM foetidum APORPHINE ALKALOIDS SELECTIVE CYTOTOXICITY GLIOMA stem cells 
Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue被引量：1
《Chinese Chemical Letters》2006年第1期5-8,共4页Hong Xia DING Wei LU Lei Xiang YANG Hai Bo LI Hua BAI Xiu Mei WU Jun Chao CAI Yu ZHAO 
Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carded out, and one of its analogue, N-methoxycepharadione ...
关键词：Artabotrine aporphine alkaloid CYTOTOXICITY synthesis. 
Two New Aporphine Alkaliods from Fissistigma bracteolatum被引量：4
《Chinese Chemical Letters》2002年第9期862-864,共3页Yu DENG Jin CHEN Feng E WU 
1,2-methylenedioxy-9-methoxy-N-methoxycarbonyl-aporphine and 1,2-methylenedioxy -8,9-dimethoxy-N-methoxycarbonyl-aporphine, two new alkaloids possessing a N-(methoxy carbonyl) group have been isolated from the stems o...
关键词：Fissistigma bracteolatum APORPHINE 1 2-methylenedioxy-9-methoxy-N-methoxy car- bonyl-aporphine 1 2-methylenedioxy -8 9-dimethoxy-N-methoxycarbonyl-aporphine. 
FUZITINE_z A NEW APORPHINE ALKALOID FROM FU ZI (ACONITUM CARMICHEALI DEBX)被引量：1
《Chinese Chemical Letters》1991年第10期787-788,共2页Hai sheng CKEN, Gong Yu HAN, Ming Zhu LIU and Hua Qing LIANG School of Pharmacy, Second Mititary Medical. Universl ty, Shanghal 200433 
A new aporphine alkaloid, named fuzitine, was isolated from the tuber of Aconitum carmicheali Debx, and its chemical structure was established'on the basis of spectral analysis and chemical reaction.
关键词：Rev FUZITINE_z A NEW APORPHINE ALKALOID FROM FU ZI ACONITUM CARMICHEALI DEBX 
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