Dopamine as a growth differentiation factor in the mammalian brain  

作　　者：Koji Ohira 

机构地区：[1]Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women’s University

出　　处：《Neural Regeneration Research》2020年第3期390-393,共4页中国神经再生研究（英文版）

基　　金：supported by Japan Society for the Promotion of Science,Grants-in-Aid for Scientific Research [grant number JP17K07084];Takeda Science Foundation

摘　　要：The catecholamine,dopamine,plays an important role in the central nervous system of mammals,including executive functions,motor control,motivation,arousal,reinforcement,and reward.Dysfunctions of the dopaminergic system lead to diseases of the brains,such as Parkinson’s disease,Tourette’s syndrome,and schizophrenia.In addition to its fundamental role as a neurotransmitter,there is evidence for a role as a growth differentiation factor during development.Recent studies suggest that dopamine regulates the development ofγ-aminobutyric acidergic interneurons of the cerebral cortex.Moreover,in adult brains,dopamine increases the production of new neurons in the hippocampus,suggesting the promoting effect of dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult brains.In this mini-review,I center my attention on dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.The catecholamine, dopamine, plays an important role in the central nervous system of mammals, including executive functions, motor control, motivation, arousal, reinforcement, and reward. Dysfunctions of the dopaminergic system lead to diseases of the brains, such as Parkinson’s disease, Tourette’s syndrome, and schizophrenia. In addition to its fundamental role as a neurotransmitter, there is evidence for a role as a growth differentiation factor during development. Recent studies suggest that dopamine regulates the development of γ-aminobutyric acidergic interneurons of the cerebral cortex. Moreover, in adult brains, dopamine increases the production of new neurons in the hippocampus, suggesting the promoting effect of dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult brains. In this mini-review, I center my attention on dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.

关 键 词：γ-aminobutyric acidergic INTERNEURON adult NEUROGENESIS cerebral CORTEX DOPAMINE GABA MEDIAL ganglionic eminence migration STRIATUM 

分 类 号：R74[医药卫生—神经病学与精神病学]