Auto-regulatory feedback by RNA-binding proteins  

作　　者：Michaela Muller-McNicoll Oliver Rossbach Jingyi Hui Jan Medenbach 

机构地区：[1]Institute of Cell Biology and Neuroscience,Goethe University Frankfurt,Max-von-Laue-Strasse 13,D-60438 Frankfurt am Main,Germany [2]Institute of Biochemistry,Justus-Liebig-University Giessen,Heinrich-Buff-Ring 17,D-35392 Giessen,Germany [3]State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China [4]Institute of Biochemistry I,University of Regensburg,Universitaetsstrasse 31,D-93053 Regensburg,Germany

出　　处：《Journal of Molecular Cell Biology》2019年第10期930-939,共10页分子细胞生物学报（英文版）

基　　金：This work was supported by the German Research Foundation(SFB902/2,B13 and CEF-MC to M.M.-M.,GRK 2355 to O.R.,SFB 960/2,Bll to J.M.);the German Federal Ministry of Education and Research(BMBF,01ZX1401D to J.M.);the LOEWE program Medical RNomics(to O.R.);the National Natural Science Foundation of China(31570820,31661143035,and 31770881 to J.H.);the National Key Research and Development Program of China(2017YFA0504400 to J.H.).

摘　　要：RNA-binding proteins(RBPs)are key regulators in post-transcriptional control of gene expression.Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of cancer.This highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of RBPs.In many cases,RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate oftheirown mRNAs,exerting control over their own expression.For this feedback control,RBPs employ a variety of mechanisms operating at all levels of posttranscriptional regulation of gene expression.Here we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range(by negative feedback)or generates binary,genetic on/off switches important for e.g.cell fate decisions(by positive feedback).

关 键 词：AUTOGENOUS REGULATION protein HOMEOSTASIS RNA-BINDING proteins POST-TRANSCRIPTIONAL REGULATION of gene expressi on 

分 类 号：R73[医药卫生—肿瘤]