RNA-BINDING

作品数：23被引量：73H指数：5
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相关领域：生物学医药卫生更多>>
相关作者：刘士勇张晓利马昕更多>>
相关机构：华中科技大学东南大学南京审计大学中国科学技术大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science China Chemistry》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33
《Acta Pharmacologica Sinica》2025年第4期1068-1081,共14页Cheng-piao Lu Jia-bin Li Dong-bao Li Yu-hong Wang Xiao-gang Jiang Jing-jing Ma Guoqiang Xu 
supported by the National Natural Science Foundation of China(32171437);the National Key R&D Program of China(2019YFA0802401);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB310017);Suzhou Science and Technology Development Project(SZM2023006);Gusu Key Health Talent Program of Suzhou(GSWS2022122);the Young Physician Scientists Program(ML42900323);Interdisciplinary Basic Frontier Innovation Program(YXY2302015)at Suzhou Medical College of Soochow University;the National Center for International Research(2017B01012);the Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
Gastric cancer is a malignant gastrointestinal disease characterized by high morbidity and mortality rates worldwide.The occurrence and progression of gastric cancer are influenced by various factors,including the abn...
关键词：RBM39 MRPL33 gastric cancer PROLIFERATION alternative splicing 
A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells
《Journal of Molecular Cell Biology》2022年第2期72-75,共4页Junyu Wu Yongheng Zhong Xue Liu Xiaoyu Lu Weijie Zeng Chunyan Wu Fan Xing Liu Cao Fuxiang Zheng Panpan Hou Hong Peng Chunmei Li Deyin Guo 
supported by the National Natural Science Foundation of China(32041002 to D.G.and 31800151 to J.W.);Guangdong Province‘Pearl River Talent Plan’Innovation and Entrepreneurship Team Project(2019ZT08Y464 to C.L.);Shenzhen Science and Technology Program(JSGG20200225150431472 and KQTD20180411143323605 to D.G.,GXWD20201231165807008 and 20200825183117001 to J.W.).
Dear Editor,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a novel emerging coronavirus that has spread worldwide since breaking out in late 2019 and has led to hundreds of millions of infections an...
关键词：ACUTE RESPIRATORY 
RNA-binding motif protein RBM47 promotes tumorigenesis in nasopharyngeal carcinoma through multiple pathways被引量：1
《Journal of Genetics and Genomics》2021年第7期595-605,共11页Chun-Ling Luo Xiao-Chen Xu Shuai He Ya-Qing Zhou Chu-Jun Liu Shu-Qiang Liu Wan Peng Yu-Xiang Liu Pan-Pan Wei Jin-Xin Bei 
supported by the National Natural Science Foundation of China(81802711);the China Postdoctoral Science Foundation(2019T120781,2018M631032,2017M622882);the Sci-Tech Project Foundation of Guangzhou City(201707020039);Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S638);the National Science Foundation for Excellent Young Scholars(81222035);Special Support Program of Guangdong(BJX);Chang Jiang Scholars Program(BJX);Key Laboratory of Carcinogenesis and Invasion,Chinese Ministry of Education(202101)。
RNA binding motif proteins(RBMs)have been widely implicated in the tumorigenesis of multiple human cancers but scarcely studied in nasopharyngeal carcinoma(NPC).Here,we compare the m RNA levels of 29 RBMs between 87 N...
关键词：RBM47 BCAT1 Alternative splicing hnRNPM Nasopharyngeal carcinoma(NPC) 
Whole-exome sequencing reveals twovariants in thegene in two Chinese patients with left ventricular non-compaction cardiomyopathy被引量：2
《Pediatric Investigation》2020年第1期11-16,共6页Qiqing Sun Jun Guo Chanjuan Hao Ruolan Guo Xuyun Hu Yuanying Chen Weili Yang Wei Li Yingjun Feng 
Importance:Pathogenic variants in theRBM20 gene are associated with aggressive dilated cardiomyopathy(DCM).Recently,RBM20 was found to be associated with left ventricular non-compaction cardiomyopathy(LVNC).Thus far,o...
关键词：Left ventricular non-compaction cardiomyopathy Dilated cardiomyopathy RNA-binding motif protein 20 Trio whole-exome sequencing 
The Expansion and Diversification of Pentatricopeptide Repeat RNA-Editing Factors in Plants被引量：1
《Molecular Plant》2020年第2期215-230,共16页Bernard Gutmann Santana Royan Mareike Schallenberg-Rudinger Henning Lenz Ian R.Castleden Rose McDowell Michael AVacher Julian Tonti-Filippini Charles SBond Volker Knoop Ian D.Small 
supported by the Australian Research Council(grant numbers FL140100179 to I.D.S.,DP150102692 to C.S.B.and I.D.S.,CE140100008 to I.D.S.,DE150101484 to B.G.);the German Research Foundation(DFG grant number SCHA1952/2-1 to M.S.-R.).
The RNA-binding pentatricopeptide repeat(PPR)family comprises hundreds to thousands of genes in most plants,but only a few dozen in algae,indicating massive gene expansions during land plant evolution.The nature and t...
关键词：RNA EDITING RNA-BINDING protein ORGANELLES 
A Plant SMALL RNA-BINDING PROTEIN 1 Family Mediates Cell-to-Cell Trafficking of RNAi Signals被引量：1
《Molecular Plant》2020年第2期321-335,共15页Yan Yan Byung-Kook Ham Yee Hang Chong Shyi-Dong Yeh William J.Lucas 
provided by the National Science Foundation(IOS-1339128 to W.J.L.).Y.H.C.was supported,in part,by a graduate fellowship provided by the National Chung-Hsing University,Taichung,China.
In plants,RNA interference(RNAi)plays a pivotal role in growth and development,and responses to environmental inputs,including pathogen attack.The intercellular and systemic trafficking of small interfering RNA(siRNA)...
关键词：RNAI SMALL RNA-BINDING PROTEIN FAMILY SMALL RNA movement non-cell-autonomous PROTEIN glycinerich PROTEIN 
Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer被引量：8
《World Journal of Gastroenterology》2019年第40期6063-6076,共14页Bai-Shun Wan Ming Cheng Ling Zhang 
Supported by the National Natural Science Foundation of China,No.61802350
BACKGROUND Studies have shown that insulin-like growth factor 2 mRNA-binding protein 1(IGF2BP1)plays critical roles in the genesis and development of human cancers.AIM To investigate the clinical significance and role...
关键词：PANCREATIC cancer INSULIN-LIKE growth factor 2 mRNA-binding protein 1 Proliferation MicroRNA-494 
IDH1 fine-tunes cap-dependent translation initiation被引量：3
《Journal of Molecular Cell Biology》2019年第10期816-828,共13页Lichao Liu JYuyang Lu Fajin Li Xudong Xing Tong Li Xuerui Yang Xiaohua Shen 
This work was supported in part by the National Natural Science Foundation of China(31471219 and 31630095);the National Basic Research Program of China(2017YFA0504204);the Center for Life Sciences at Tsinghua University.
The metabolic enzyme isocitrate dehydrogenase 1(IDH1)catalyzes the oxidative decarboxylation of isocitrate to a-ketoglutarate(a-KG).Its mutation often leads to aberrant gene expression in cancer.IDH1 was reported to b...
关键词：IDH1 PROTEOMIC INTERACTOME translation regulation RNA-BINDING protein 
Marking RNA:m^6A writers,readers,and functions in Arabidopsis被引量：15
《Journal of Molecular Cell Biology》2019年第10期899-910,共12页Marlene Reichel Tino Koster Dorothee Staiger 
N^6-methyladenosine(m^6A)emerges as an important modification in eukaryotic mRNAs.m^6A has first been reported in 1974,and its functional significance in mammalian gene regulation and importance for proper development...
关键词：ARABIDOPSIS m^6A mRNA INTERACTOME POSTTRANSCRIPTIONAL RNA-BINDING protein 
Auto-regulatory feedback by RNA-binding proteins被引量：5
《Journal of Molecular Cell Biology》2019年第10期930-939,共10页Michaela Muller-McNicoll Oliver Rossbach Jingyi Hui Jan Medenbach 
This work was supported by the German Research Foundation(SFB902/2,B13 and CEF-MC to M.M.-M.,GRK 2355 to O.R.,SFB 960/2,Bll to J.M.);the German Federal Ministry of Education and Research(BMBF,01ZX1401D to J.M.);the LOEWE program Medical RNomics(to O.R.);the National Natural Science Foundation of China(31570820,31661143035,and 31770881 to J.H.);the National Key Research and Development Program of China(2017YFA0504400 to J.H.).
RNA-binding proteins(RBPs)are key regulators in post-transcriptional control of gene expression.Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative diso...
关键词：AUTOGENOUS REGULATION protein HOMEOSTASIS RNA-BINDING proteins POST-TRANSCRIPTIONAL REGULATION of gene expressi on 
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