POST-TRANSCRIPTIONAL

作品数：32被引量：212H指数：7
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相关机构：清华大学科尔盖特大学更多>>
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NAT10 primes a post-transcriptional repertoire essential for the maintenance of spermatogonial homeostasis
《Science Bulletin》2025年第6期842-846,共5页Xiaoli Zhu Caoling Xu Xue Jiang Jiaqi Zou Wenqing Li Xuemei Xing Xiaoxiao Gao Jiao Lei Fei Meng Xin Wang Yuzhang Zhu Yu Cheng Muhammad Azhar Wenjie Han Ge Lin Yunfang Zhang Ge Shan Shen Zhang Jianqiang Bao 
supported by the National Key Research and Development Program ofChina(2019YFA0802600,2022YFC2702600);Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM"(QYPY20230032);the National Natural Science Foundation of China(31970793,32170856 and 32300711);the Anhui Provincial Natural Science Foundation grant(2408085jJ016);the Reproductive and Genetic Hospital of CITIC-XIANGYA(YNXM-202211);the Hunan Provincial Grant for Innovative Province Construction(2019SK4012);the Hundred Youth Talents Program of Hunan Province.
Male fertility is built on the proper proliferation and differentiation of germline cells within the seminiferous epithelium in the testis,which continuously produces millions of sperm per day in mammals[1].RNA modifi...
关键词：proliferation differentiation germline cells post transcriptional regulation germline cells male fertility spermatogonial homeostasis epitranscriptomic regulators seminiferous epithelium 
Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming被引量：2
《Neural Regeneration Research》2024年第9期1929-1939,共11页Elsa Papadimitriou Dimitra Thomaidou 
supported by Stavros Niarhos Foundation;Greek‘Flagship Action for the Study of Neurodegenerative Diseases on the Basis of Precision Medicine’(to DT).
Neurogenesis is a tightly regulated process in time and space both in the developing embryo and in adult neurogenic niches.A drastic change in the transcriptome and proteome of radial glial cells or neural stem cells ...
关键词：direct neuronal reprogramming in vivo glia-to-neuron conversion microRNAs NEUROGENESIS post-transcriptional regulation RNA binding proteins 
Chloroplast gene expression:Recent advances and perspectives被引量：3
《Plant Communications》2023年第5期153-171,共19页Yi Zhang Lin Tian Congming Lu 
supported by the National Key Research and Development Program of China(grant no.2020YFA0907600);the National Natural Science Foundation of China(grant nos.31730102 and 32000184);the Natural Science Foundation of Shandong Province(grant no.ZR2020QC023);the China Postdoctoral Science Foundation(grant no.2020M672093).
Chloroplasts evolved from an ancient cyanobacterial endosymbiont more than 1.5 billion years ago.During subsequent coevolution with the nuclear genome,the chloroplast genome has remained independent,albeit strongly re...
关键词：CHLOROPLAST chloroplast gene expression TRANSCRIPTION post-transcriptional processing TRANSLATION 
Coordinated transcriptional and post-transcriptional epigenetic regulation during skeletal muscle development and growth in pigs
《Journal of Animal Science and Biotechnology》2023年第2期564-577,共14页Du Zhang Shumei Wu Xinxin Zhang Shuqiang Ren Zhonglin Tang Fei Gao 
supported by the Agricultural Science and Technology Innovation Program and The Elite Young Scientists Program of CAAS.ZT was supported by the National Natural Science Foundation of China(31830090);the Basic and Applied Basic Research Foundation of Guangdong province(2019B1515120059);the Shenzhen Dapeng New District Special Fund for Industry Development(KY20180114);the Agricultural Science and Technology Innovation Program(CAAS-ZDRW202006).
Background:N6-methyladenosine(m^(6)A)and DNA 5-methylcytosine(5mC)methylation plays crucial roles in diverse biological processes,including skeletal muscle development and growth.Recent studies unveiled a potential li...
关键词：DNA methylation Epigenetic modification Epigenomic analysis 5mC regulators m^(6)A methylation m^(6)A regulators MYOGENESIS 
RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits被引量：1
《Protein & Cell》2023年第1期51-63,共13页Yue Lv Gang Lu Yuling Cai Ruibao Su Liang Liang Xin Wang Wenyu Mu Xiuqing He Tao Huang Jinlong Ma Yueran Zhao Zi-Jiang Chen Yuanchao Xue Hongbin Liu Wai-Yee Chan 
supported by grants from the National Key R&D Program of China(2021YFC2700200);Academic Promotion Programme of Shandong First Medical University(2019U001);General Research Fund from Research Grants Council of Hong Kong(14103418);Basic Science Center Program of NFSC(31988101);the Shandong Provincial Key Research and Development Program(2020ZLYS02);a fund from A-Smart Group to support CUHKSDU Joint Laboratory on Reproductive Genetics of CUHK,Major Innovation Projects in Shandong Province(2021ZDSYS16);the Science Foundation for Distinguished Yong Scholars of Shandong(ZR2021JQ27);Taishan Scholars Program for Young Experts of Shandong Province(tsqn202103192).
RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain unknown.Here,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRN...
关键词：RBM46 LACE-seq RNA-binding protein MEIOSIS COHESIN 
MicroRNAs expression dynamics reveal post-transcriptional mechanisms regulating seed development in Phaseolus vulgaris L.被引量：1
《Horticulture Research》2021年第1期195-211,共17页Jose Ricardo Parreira Michela Cappuccio Alma Balestrazzi Pedro Fevereiro Susana de Sousa Araujo 
The knowledge on post-transcriptional regulation mechanisms implicated in seed development(SD)is still limited,particularly in one of the most consumed grain legumes,Phaseolus vulgaris L.We explore for the first time ...
关键词：MECHANISMS dynamics REGULATING 
Woodchuck hepatitis post-transcriptional regulatory element improves transgene expression and stability mediated by episomal vectors in CHO-K1 cells被引量：2
《Acta Biochimica et Biophysica Sinica》2020年第11期1285-1288,共4页Xiaoyin Wang Weili Zhang Yanlong Jia Meng Wang Dandan Yi Tian-yun Wang 
the grants from the National Nat-ural Science Foundation of China(No.U1804168);the Plan of Scientific and Technological Innovation Team for University,Henan Province,China(No.18IRTSTHN027);the Key Science and Tech-nology Project of Henan(No.192102310149);the Key Sci-entific Research Project of Universities of Henan Province(No.18A350008).
Gene therapy is an effective strategy for treating several diseases,and safe and efficient vector systems are the basis for gene therapy applications.The non-viral episomal vectors are preferred as a gene transfer too...
关键词：MEDIATED diseases INSERTION 
Production of very-high-amylose cassava by post-transcriptional silencing of branching enzyme genes被引量：3
《Journal of Integrative Plant Biology》2020年第6期832-846,共15页Wenzhi Zhou Shanshan Zhao Shutao He Qiuxiang Ma Xinlu Lu Xiaomeng Hao Hongxia Wang Jun Yang Peng Zhang 
the grants from the National Key R&D Program of China“Development and Regulation of Economically Important Traits in Tropical Crops(2018YFD1000500);the National Natural Science Foundation of China(31871682);the National Key Technology Research and Development Program of China(2015BAD15B01);the Collaborative Innovation Action—Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAASXTCX2016009);the Earmarked Fund for China Agriculture Research System(CARS-11-shzp)。
High amylose starch can be produced by plants deficient in the function of branching enzymes(BEs).Here we report the production of transgenic cassava(Manihot esculenta Crantz)with starches containing up to 50%amylose ...
关键词：CHAINS branching PATTERN 
MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest被引量：3
《Neural Regeneration Research》2019年第11期2003-2010,共8页Xiao-Hua Wang Dong-Xu Yao Xiu-Shu Luan Yu Wang Hai-Xia Liu Bei Liu Yang Liu Lei Zhao Xun-Ming Ji Tian-Long Wang 
supported by the National Natural Science Foundation of China,No.81401084(to XHW);the Beijing Municipal Administration of Hospital Ascent Plan in China,No.DFL20150802(to TLW);the Beijing 215 High Level Healthcare Talent Plan Academic Leader in China,No.008-0027(to TLW);the Beijing Municipal Commission of Health and Family Planning in China,No.PXM2017_026283_000002(to TLW);the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support in China,No.ZYLX201706(to TLW),303-01-005-0137-11(to TLW),65683.00(to TLW)
Using deep hypothermic circulatory arrest, thoracic aorta diseases and complex heart diseases can be subjected to corrective procedures. However, mechanisms underlying brain protection during deep hypothermic circulat...
关键词：NERVE REGENERATION cerebral protection deep hypothermic circulatory ARREST gene ontology enrichment analysis microRNA hippocampus POST-TRANSCRIPTIONAL expression MICROARRAY bioinformatics neural REGENERATION 
Auto-regulatory feedback by RNA-binding proteins被引量：5
《Journal of Molecular Cell Biology》2019年第10期930-939,共10页Michaela Muller-McNicoll Oliver Rossbach Jingyi Hui Jan Medenbach 
This work was supported by the German Research Foundation(SFB902/2,B13 and CEF-MC to M.M.-M.,GRK 2355 to O.R.,SFB 960/2,Bll to J.M.);the German Federal Ministry of Education and Research(BMBF,01ZX1401D to J.M.);the LOEWE program Medical RNomics(to O.R.);the National Natural Science Foundation of China(31570820,31661143035,and 31770881 to J.H.);the National Key Research and Development Program of China(2017YFA0504400 to J.H.).
RNA-binding proteins(RBPs)are key regulators in post-transcriptional control of gene expression.Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative diso...
关键词：AUTOGENOUS REGULATION protein HOMEOSTASIS RNA-BINDING proteins POST-TRANSCRIPTIONAL REGULATION of gene expressi on 
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