ORGANELLES

作品数：43被引量：94H指数：4
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相关领域：生物学更多>>
相关作者：袁宗飞徐是雄国凤利孙亮胡适宜更多>>
相关机构：北京大学香港大学中国农业大学中山大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Smart Molecules》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Recent advances in single fluorescent probes for monitoring dual organelles in two channels
《Smart Molecules》2024年第4期167-196,共30页Xiu-Zhi Yang Shankun Yao Jisong Wu Jiajie Diao Weijiang He Zijian Guo Yuncong Chen 
support from the National Natural Science Foundation of China(22122701,22477054,22293050,91953201,92153303,22377050);the Excellent Research Program of Nanjing University(ZYJH004);the Natural Science Foundation of Jiangsu Province(BK20232020).
Organelles are specialized areas where cells perform specific processes necessary for life and actively communicate with each other to keep the whole cell func-tioning.Disorders of the organelle networks are associate...
关键词：BIOIMAGING dual-color dual-targeted fluorescent probes organelle interaction 
Label-free Super-resolution Microscopy for Long-term Monitoring the Dynamic Interactions of Cellular Organelles
《Chemical Research in Chinese Universities》2024年第6期994-1003,共10页SHAO Lina SUN Minglu ZHANG Jinrui XU Haijiao YANG Hui LI Hongru WANG Huili CUI Zongqiang LI Dayu WANG Hongda 
supported by the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.ZDKYYQ20220005);the National Natural Science Foundation of China(Nos.22150003,and 22327808);Chinese patent applications have been submitted for relevant technologies(No.202011538556.8,No.202110126844.0&No.ZL 202120587363.5).
The ideal method for imaging living cells is one that allows for long-term,label-free observation in real-time with super-resolution capabilities.Such a method would overcome the drawbacks of phototoxicity and photobl...
关键词：LABEL-FREE SUPER-RESOLUTION Fourier ptychography microscopy Long-term Cellular organelle SARS-CoV-2 virus-like particle 
Membraneless organelles in health and disease:exploring the molecular basis,physiological roles and pathological implications
《Signal Transduction and Targeted Therapy》2024年第12期5513-5538,共26页Yangxin Li Yuzhe Liu Xi-Yong Yu Yan Xu Xiangbin Pan Yi Sun Yanli Wang Yao-Hua Song Zhenya Shen 
supported by the National Natural Science Foundation of China(82370264 to Y.Li,82370501 to Y.H.S.,81870194 and 91849122 to Y.Li,92168203 to Z.S.);Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK12023023 to Y.Li);Jiangsu Cardiovascular Medicine Innovation Center(CXZX202210);China Postdoctoral Science Foundation(No.2021M702394 to Y.W.);Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB578 to Y.W.);.The project for the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);The National Key Research and Development Program of China(2022YFE0209700)to X.Y.Translational Research Grant of NCRCH(2020WSB07).
Once considered unconventional cellular structures,membraneless organelles(MLOs),cellular substructures involved in biological processes or pathways under physiological conditions,have emerged as central players in ce...
关键词：METABOLISM apparatus PHYSIOLOGICAL 
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors
《Journal of Pharmaceutical Analysis》2024年第8期1110-1124,共15页Meiyu Qu Qiangqiang He Hangyang Bao Xing Ji Tingyu Shen Muhammad Qasim Barkat Ximei Wu Ling-Hui Zeng 
the financial support from the National Natural Science Foundation of China(Grant Nos.:31571493,81741043,31871395,and 32170841).
Arsenic compounds are widely used for the therapeutic intervention of multiple diseases.Ancient pharmacologists discovered the medicinal utility of these highly toxic substances,and modern pharmacologists have further...
关键词：Arsenic compounds Phase separation Membraneless organelles PML Stress granules 
Mammalian integrated stress responses in stressed organelles and their functions被引量：2
《Acta Pharmacologica Sinica》2024年第6期1095-1114,共20页Hao-jun Lu Nirmala Koju Rui Sheng 
supported by grants from the National Natural Science Foundation of China(No.82173811,81973315);Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD)and Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases.
The integrated stress response(ISR)triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions.Four kinases(P...
关键词：integrated stress response ORGANELLES eukaryotic translation initiation factor 2 activating transcription factor 4 protein homeostasis 
Abnormal phase separation of biomacromolecules in human diseases
《Acta Biochimica et Biophysica Sinica》2023年第7期1133-1152,共20页Songhao Zhang Gaofeng Pei Boya Li Pilong Li Yi Lin 
supported by the grants from the National Natural Science Foundation of China(Nos.32170684 to Y.L.,32150023 and 32125010 to P.L.);the Ministry of Science and Technology of the People’s Republic of China(Nos.2022ZD0213900 and 2022ZD0204900 to Y.L.);the National Key Research and Development Program of China(No.2019YFA0508403 to P.L.)。
Membrane-less organelles(MLOs)formed through liquid-liquid phase separation(LLPS)are associated with numerous important biological functions,but the abnormal phase separation will also dysregulate the physiological pr...
关键词：membrane-less organelles developmental disorder tandem repeat disorder cancer infectious diseases abnormal phase separation 
Predicting assembly mode of membraneless organelles by a FRET-based crowding sensor
《Signal Transduction and Targeted Therapy》2023年第7期3225-3227,共3页Feng Chen Siyuan Shen Xu Cao Liang Zhang Lunxu Liu Daoke Yang Yunyu Shi Wei He Xuebiao Yao Dan Liu 
This work was jointly supported by grants from the National Natural Science Foundation of China(32090041,D.L.);the Major Research Plan of the National Natural Science Foundation of China(2016YFA0101200,D.L.).This work was also supported in part by the CAS Key Laboratory of Innate Immunity and Chronic Disease.We are grateful to Prof.Yucai Wang and Prof.Chunlei Cang for providing experimental instruments and equipments,especially confocal microscopes.We appreciate Prof.Wei Xiong and Dr.Yushu Ge for their help and advice in the process of writing this letter.We thank Mr.Zhao Yue for his help in the data processing process.We also thank our colleagues Ms.Yun Wang,Ms.Mengtong Qin and Ms.Yu Chen for their help during the experiment.
Dear Editor,Biomacromolecules aggregate to form membraneless organelles(MLOs)via phase separation has been observed in a variety of physiological processes over the last decade.1 However,the molecular basis of biomacr...
关键词：SEPARATION methods MODE 
Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance被引量：1
《Neural Regeneration Research》2023年第5期1009-1016,共8页Marina G.Yefimova 
The timely and efficient elimination of aberrant proteins and damaged organelles, formed in response to various genetic and environmental stressors, is a vital need for all cells of the body. Recent lines of evidence ...
关键词：autophagy Huntington’s disease Müller cells myelinosome-driven secretion myelinosomes ocular pathophysiology PROTEOSTASIS retina retinal pigmented epithelium ubiquitin-proteasome system 
Phase-separated bienzyme compartmentalization as artificial intracellular membraneless organelles for cell repair
《Science China Chemistry》2023年第3期845-852,共8页Yanwen Zhang Shixin Wang Yuling Yan Xiaoxiao He Zefeng Wang Shaohong Zhou Xiaohai Yang Kemin Wang Jianbo Liu 
supported by the National Natural Science Foundation of China(21735002,22177032,32101082);the Science Fund for Distinguished Young Scholars of Hunan Province(2021JJ10013);the Hunan Province Innovative Talent Funding for Postdoctoral Fellows(2021RC2059);the Postdoctoral Science Foundation of China(2021TQ0103,2021M690957).
Implanting artificial organelles in living cells is capable of correcting cellular dysfunctionalities for cell repair and biomedical applications. In this work, phase-separated bienzyme-loaded coacervate microdroplets...
关键词：artificial membraneless organelles coacervate microdroplets nitric oxide liquid-liquid phase separation cell repair 
Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps
《Journal of Molecular Cell Biology》2023年第2期1-2,共2页Sheng Zhou Hongyu Deng 
As intracellular parasites,viruses must modulate the environment of host cells to facilitate viral genome replication and virion assembly.One strategy is to establish specialized,membrane-associated subcellular struct...
关键词：al. STEPS utilized 
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