胶红酵母生产生物活性物质研究进展  

Bioactive Substances Produced by Rhodotorula mucilaginosa: A Comprehensive Review

作　　者：庄荣玉[1,2] 王如晨 邱晓挺 车嘉豪 李勇勇 张蔚筱 杨文鸽 史咏梅[1] 吴祖芳 ZHUANG Rongyu;WANG Ruchen;QIU Xiaoting;CHE Jiahao;LI Yongyong;ZHANG Weixiao;YANG Wenge;SHI Yongmei;WU Zufang(College of Food and Pharmaceutical Sciences,Ningbo University,Ningbo 315800,China;Key Laboratory of Animal Protein Foods Deep Processing of Zhejiang Province,Ningbo 315800,China)

机构地区：[1]宁波大学食品与药学学院,浙江宁波315800 [2]浙江省动物蛋白食品精深加工重点实验室,浙江宁波315800

出　　处：《食品科学》2020年第1期318-329,共12页Food Science

基　　金：宁波市科技局科技富民项目（2017C10034）;浙江省科技厅公益技术应用研究计划项目（2017C33009）

摘　　要：胶红酵母为红酵母属物种,具有较强的环境适应力,广泛存在于不同生态系统环境中。其菌体含有蛋白质、天然类胡萝卜素、β-胡萝卜素、虾青素、多不饱和脂肪酸和维生素等多种营养成分和生物活性物质,是很有潜力的工业生产菌株。本文重点综述了胶红酵母在番茄红素、β-胡萝卜素、虾青素和ω-3系列的α-亚麻酸功能性食用油脂等生物活性物质领域的应用研究进展,主要包括高产菌株筛选、基因工程菌株的构建、发酵工艺和提取工艺等,介绍了其在共培养漆酶、角质酶和全细胞生物转化先导化合物制备新型药物方面的应用。The red yeast Rhodotorula mucilaginosa is a species belonging to the genus Rhodotorula. It is widely distributed in various ecosystems because of its strong adaptability to different environments. R. mucilaginosa appears to be a very promising industrial strain due to its ability to produce proteins and bioactive substances such as natural carotenoids, β-carotene, astaxanthin, polyunsaturated fatty acids(PUFA) and vitamins. This review summarizes the available data in the literature on the research and application of R. mucilaginosa in the production of lycopene, β-carotene, astaxanthin and alpha-linolenic acid and functional edible oils rich in the essential dietary ω-3 fatty acid, α-linolenic acid(ALA). Its focus is on screening for high-yield strains, construction of genetically engineered strains, and the fermentation and extraction processes as well as the applications of R. mucilaginosa in production of laccase by co-culture, cutinase and in the preparation of novel drugs from whole-cell biotransformation lead compounds.

关 键 词：胶红酵母 类胡萝卜素 Α-亚麻酸 Ω-3多不饱和脂肪酸 漆酶 角质酶 生物催化剂 

分 类 号：TS201.1[轻工技术与工程—食品科学]