The role of exercise in brain DNA damage  

作　　者：Thais Cereser Vilela Vanessa Moraes de Andrade Zsolt Radak Ricardo Aurino de Pinho 

机构地区：[1]Laboratory of Translational Biomedicine,Graduate Program of Health Sciences,University of Southern Santa Catarina–UNESC,Criciuma,SC,Brazil [2]Research Institute of Sport Science,University of Physical Education,Budapest,Hungary [3]Laboratory of Exercise Biochemistry in Health,Graduate Program in Health Sciences,School of Medicine,Pontificia Universidade Catolica do Parana,Curitiba,PR,Brazil

出　　处：《Neural Regeneration Research》2020年第11期1981-1985,共5页中国神经再生研究（英文版）

摘　　要：Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA,which leads to neuronal death.In this way,DNA damage has been implicated in the pathogenesis of neurological disorders,cancer,and aging.Lifestyle factors,such as physical exercise,are neuroprotective and increase brain function by improving cognition,learning,and memory,in addition to regulating the cellular redox milieu.Several mechanisms are associated with the effects of exercise in the brain,such as reduced production of oxidants,up-regulation of antioxidant capacity,and a consequent decrease in nuclear DNA damage.Furthermore,physical exercise is a potential strategy for further DNA damage repair.However,the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown.In this review,we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain.We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.

关 键 词：aerobic EXERCISE apoptosis BRAIN-DERIVED NEUROTROPHIC factor BRAIN DNA damage DNA repair NEURODEGENERATIVE disease oxidative stress physical EXERCISE strength EXERCISE 

分 类 号：R873[医药卫生—运动医学]