The role of telomere-binding modulators in pluripotent stem cells  

作　　者：Feng Li Yuanlong Ge Dan Liu Zhou Songyang 

机构地区：[1]State Key Laboratory of Oncology in South China,Cancer Center,Collaborative Innovation Center for Cancer Medicine,and Key Laboratory of Gene Engineering of the Ministry of Education,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China [2]Verna and Marrs Department of Biochemistry and Molecular Biology,Baylor College of Medicine,One Baylor Plaza,Houston,TX 77030,USA

出　　处：《Protein & Cell》2020年第1期60-70,共11页蛋白质与细胞（英文版）

基　　金：supported by National Natural Science Foundation of China(Grant Nos.81871109,31401223,81330055,31570827,91749113,91640119 and 31871479);National Key Research and Development Program of China(2017YFA0102801,2018YFA0107003);Natural Science Foundation of Guangdong Province(2017A030313116).

摘　　要：Pluripotent stem cells(PSCs)such as embryonic stem cells(ESCs),ESCs derived by somatic cell nuclear transfer(ntESCs),and induced pluripotent stem cells(iPSCs)have unlimited capacity for self-renewal and pluripotency and can give rise to all types of somatic cells.In order to maintain their self-renewal and pluripotency,PSCs need to preserve their telomere length and homeostasis.In recent years,increasing studies have shown that telomere reprogramming is essential for stem cell pluripotency maintenance and its induced pluripotency process.Telomere-associated proteins are not only required for telomere maintenance in both stem cells,their extra-telomeric functions have also been found to be critical as well.Here,we will discuss how telomeres and telomere-associated factors participate and regulate the maintenance of stem cell pluripotency.

关 键 词：TELOMERE PLURIPOTENT STEM cells TELOMERASE ALT shelterin/telosome complex 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]