Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy  

作　　者：Ling Zhang Chengguang Sui Wenhan Yang Qiuhua Luo 

机构地区：[1]Department of Biotherapy,The First Affiliated Hospital of China Medical University,Shenyang 110001,China [2]Department of Pharmacy,The First Affiliated Hospital of China Medical University,Shenyang 110001,China [3]Department of Pharmacy,China Medical University,Shenyang 110001,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2020年第2期192-206,共15页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.81803442 and 81703425).

摘　　要：Amino acid transporters,which play a vital role in transporting amino acids for the biosynthesis of mammalian cells,are highly expressed in types of tumors.Increasing studies have shown the feasibility of amino acid transporters as a component of tumortargeting therapy.In this review,we focus on tumor-related amino acid transporters and their potential use in tumor-targeting therapy.Firstly,the expression characteristics of amino acid transporters in cancer and their relationship with tumor growth are reviewed.Secondly,the recognition requirements are discussed,focusing on the“acidbase”properties,conformational isomerism and structural analogues.Finally,recent developments in amino acid transporter-targeting drug delivery strategies are highlighted,including prodrugs and nanocarriers,with special attention to the latest findings of molecular mechanisms and targeting efficiency of transporter-mediated endocytosis.We aim to offer related clues that might lead to valuable tumor-targeting strategies by the utilization of amino acid transporters.

关 键 词：AMINO acid TRANSPORTER TUMOR-TARGETING Drug delivery PRODRUG NANOCARRIERS 

分 类 号：R943[医药卫生—药剂学]