Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases  

作　　者：Henrik HHansen Urmas Roostalu Jacob Hecksher-Sorensen 

机构地区：[1]Gubra,Hprsholm,Denmark

出　　处：《Neural Regeneration Research》2020年第12期2255-2257,共3页中国神经再生研究（英文版）

摘　　要：Quantitative histopathology in preclinical neuroscience:Altered brain functionality in neurodegenerative diseases,including Parkinson’s disease(PD)and Alzheimer’s disease(AD),involve complex pathological changes and molecular mechanisms which poses a major challenge for development of effective drug treatments.Progressive loss of specific neuron types and projections are hallmarks of PD and AD and proper histological evaluation of relevant disease models therefore requires highly reliable cell detection.

关 键 词：DRUG TREATMENT ALZHEIMER 

分 类 号：R741[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]