嗜热链球菌MN-BM-A01对小鼠免疫的调节作用  

Immunoregulatory Effect of Streptococcus thermophilus MN-BM-A01 on Mice

作　　者：陈云 李周勇[2] 史玉东[2] 王然[3] 王辰元 赵亮 Chen Yun;Li Zhouyong;Shi Yudong;Wang Ran;Wang Chenyuan;Zhao Liang(Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Food Science&Nutritional Engineering,China Agricultural University,Beijing 1000832;Inner Mongolia Meng Niu Dairy Industry(Group)Co.Ltd.R&D Center,Hohhot 011500;Beijing Laboratory for Food Quality and Safety,Beijing 100083)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京食品营养与人类健康高精尖创新中心,北京100083 [2]内蒙古蒙牛乳业(集团)股份有限公司研发中心,呼和浩特011500 [3]食品质量与安全北京实验室,北京100083

出　　处：《中国食品学报》2020年第7期53-58,共6页Journal of Chinese Institute Of Food Science and Technology

基　　金：北京市科技计划课题(Z181100009318005)。

摘　　要：目的:研究嗜热链球菌MN-BM-A01对小鼠免疫的调节作用。方法:以雄性昆明小鼠为动物模型,测定小鼠体重及免疫脏器指数、血清中IgG和IgM含量、粪便中sIgA含量的变化,评价该菌株的免疫调节作用。结果:MN-BM-A01对小鼠脾脏有显著影响,对胸腺没有显著影响;该菌可有效提高小鼠血清中IgG、IgM的含量以及小鼠粪便中s IgA的含量;细胞免疫中的淋巴细胞转化试验和单核-巨噬细胞功能测定中的碳廓清试验显示阳性反应。结论:MN-BM-A01菌株具有增强小鼠免疫力的作用。To study the immunoregulatory effect of Streptococcus thermophilus MN-BM-A01 on mice,male kunming mice as animal model,weight and index of immune organs in mice,mice serum IgG and IgM content,sIgA levels in mouse excrement were determined.At the same time,the immunoregulatory effects of MN-BM-A01 was studied by evaluation experiments.Results showed that MN-BM-A01 had no adverse effects on health in mice,the mice spleen changes had a significant impact,in mice thymus changes had little impact;MN-BM-A01 can improve the content of serum IgG,IgM and sIgA levels in mice feces effectively.In the test of evaluate the immune regulation of MN-BM-A01,lymphocyte transformation test of cellular immunity and clearance rate of carbon test of mononuclear macrophage function indexes,in the determination of all have two or more dosage group showed positive.Conclusion:MN-BM-A01 could enhanced the role of immunity in mice.

关 键 词：嗜热链球菌 MN-BM-A01 免疫调节 

分 类 号：TS201.3[轻工技术与工程—食品科学]