Psychosis symptoms following aberrant immunity in the brain  

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作  者:Akitoshi Ozaki Yuki Yamawaki Gen Ohtsuki 

机构地区:[1]Department of Biophysics,Kyoto University Graduate School of Science,Kyoto,Japan [2]The Hakubi Center for Advanced Research,Kyoto University,Kyoto,Japan [3]Department of Drug Discovery Medicine,Kyoto University Graduate School of Medicine,Kyoto,Japan

出  处:《Neural Regeneration Research》2021年第3期512-513,共2页中国神经再生研究(英文版)

基  金:supported by grants from the Kowa Life Science Foundation;the Japanese Society for Promotion of Science(KAKENHI,Grant-in-Aid for Young Scientists(A)26710002);the Brain Science Foundation;the Tokyo Biochemical Research Foundation;the Naito Foundation;the Hakubiproject grant(Kyoto University)(all to GO)。

摘  要:Neuroinflammation in the brain is thought related to the emergence of various psychoses,although the identifying regional significance,the involvement of immune-cells and lymphocytic activity,and ways for the therapeutic recovery are under the effort of researchers.We recently revealed that the cerebellar acute inflammation causes the symptoms manifested in mood disorders or developmental disorders,which were associated with hyperexcitability due to immune-triggered plasticity and the overconnectivity between the inflamed cerebellum and prefrontal cortex(Yamamoto et al.,2019).

关 键 词:INFLAMMATION IMMUNITY INVOLVEMENT 

分 类 号:R749[医药卫生—神经病学与精神病学]

 

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