Review: Pathogenesis of cholestatic liver diseases  

作　　者：Raquel T Yokoda Eduardo A Rodriguez 

机构地区：[1]Department of Anatomic and Clinical Pathology,Montefiore Medical Center,Albert Einstein College of Medicine,Bronx,NY 10467,United States [2]Department of Gastroenterology,Hepatology and Nutrition,University of Utah,Salt Lake City,UT 84132,United States

出　　处：《World Journal of Hepatology》2020年第8期423-435,共13页世界肝病学杂志（英文版）（电子版）

摘　　要：Cholestatic liver diseases(CLD)begin to develop after an impairment of bile flow start to affect the biliary tree.Cholangiocytes actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of CLD.Progressive cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver transplantation.This narrative review will discuss cholangiocyte biology and pathogenesis mechanisms involved in four intrahepatic CLD:Primary biliary cholangitis,primary sclerosing cholangitis,cystic fibrosis involving the liver,and polycystic liver disease.

关 键 词：CHOLESTASIS CHOLANGITIS EPIGENOMICS IMMUNOGENETICS PATHOGENESIS Bile acid 

分 类 号：R575[医药卫生—消化系统]