两种红曲菌固态发酵产莫纳可林K和桔霉素的比较  

Comparison of monacolin K and citrinin production by two Monascus species in red yeast rice

作　　者：李志强[1] 刘颖[1] 林风[1] 吴丽云[1] LI Zhiqiang;LIU Ying;LIN Feng;WU Liyun(Fujian Engineering and Research Center for Microbial Techniques of Hongqu,Fujian Institute of Microbiology,Fuzhou 350007,China)

机构地区：[1]福建省微生物研究所,福建省红曲微生物技术开发应用工程研究中心,福建福州350007

出　　处：《食品与发酵工业》2020年第17期94-98,共5页Food and Fermentation Industries

基　　金：福建省公益类科研院所专项(2018R1009-3,2018R1009-5,2019R1005-7);福建省财政厅省直教育科研专项(闽财指[2015]1297号);福建省红曲微生物技术开发应用工程研究中心项目(闽发改高技【2017】513号);国家“重大新药创制”科技重大专项(2019ZX09201005-001-003)。

摘　　要：红曲菌可产生具有降血脂功能的莫纳可林K,但部分菌株产生的桔霉素引起了人们对红曲产品安全性的担忧。选取11株紫色红曲菌和10株红色红曲菌,通过高效液相色谱法分析各菌株固态发酵所产红曲米中莫纳可林K和桔霉素的含量。结果表明,11株紫色红曲菌和4株红色红曲菌可产生桔霉素,1株紫色红曲菌和9株红色红曲菌可产生莫纳可林K。其中5株红色红曲菌所生产的红曲中莫纳可林K和桔霉素含量符合QB/T 2847—2007《功能性红曲(米粉)》。该结果可为修改红曲产品相关标准提供有价值的信息。Monacolin K(MK,also known as lovastatin),produced by fermenting steamed rice with Monascus sp.,is a beneficial secondary metabolite which has hypocholesterolemic effects.While some Monascus strains can produce the mycotoxin citrinin,which gives rise to a controversy over the safety of Monascus fermented products.In this study,11 Monascus purpureus and 10 Monascus ruber strains were selected,and the contents of MK and citrinin in red yeast rice produced by these strains were analyzed with high performance liquid chromatography(HPLC).All 11 M.purpureus strains and 4 M.ruber strains could produce citrinin,while a M.purpureus strain and 9 M.ruber strains could produce MK.The contents of MK and citrinin in fermented rice produced by 5 M.ruber strains met the standards of functional red yeast rice(QB/T 2847—2007).The results from this study provide valuable information for modifying standards of related functional red yeast rice.

关 键 词：紫色红曲菌 红色红曲菌 莫纳可林K 桔霉素 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]