基于复杂分子结构模型建构的项目教学案例——探秘血红素  

Project Teaching Case Based on Complex Molecular Structure Model Construction: Exploration of Heme

作　　者：王全 陈颖[2] 沈煜新 魏锐[1] 邹紫微 王聪 王磊[1,4] WANG Quan;CHEN Ying;SHEN Yu-Xin;WEI Rui;ZOU Zi-Wei;WANG Cong;WANG Lei(College of Chemistry,Beijing Normal University,Beiing 100875,China;Haidian Teacher Training Collge,Beijing 100097,China;Daxing No.1 Middle School,Bejing 102600,China;Bejing Advanced Innovation Center for Future Education,Beiing 102206,China)

机构地区：[1]北京师范大学化学学院,北京100875 [2]北京市海淀区教师进修学校,北京100089 [3]北京市大兴区第一中学,北京102600 [4]北京师范大学未来教育高精尖创新中心,北京100875

出　　处：《化学教育（中英文）》2020年第17期35-42,共8页Chinese Journal of Chemical Education

基　　金：北京师范大学化学学院化学教育研究团队“新课标、新教材、新教学、新评价”高端备课教学改进项目。

摘　　要：本研究基于可视化软件VESTA和生物大分子空间结构数据库(PDB)将血红蛋白的结构模型可视化,切割出其功能单元"血红素"并将其晶胞内分数坐标转化为可供学生搭建的三维直角坐标。在课堂上尽可能还原了科学家破解复杂分子结构的一般方法及步骤,学生在项目实施过程中动手搭建血红素原子位置模型,利用键长数据判断原子间的成键关系,并利用模型解释血红蛋白载氧和中毒的机理,发展了证据推理与模型认知等学科核心素养。The 2017 high school chemistry curriculum standard adjusts the curriculum structure. Material structure and nature are one of the modules of the optional compulsory courses. The curriculum standard requires students to master not only the specific knowledge about the microstructure of matters, but also establish the method of research and recognize the microstructure of matters, develop the core competence in discipline such as evidence reasoning and model cognition. Based on the visualization software VESTA and the Protein Data Bank(PDB), this study visualizes the structural model of hemoglobin, cuts out its functional unit "heme" and converts its intracellular fractional coordinates into three-dimensional cartesian coordinates for students to build. In the classroom, the general methods and steps of scientists to solve complex molecular structures are restored as much as possible. Students construct the heme atomic position model during project implementation, use the bond length data to judge the bond relationship between atoms, and use the model to explain the mechanism of hemoglobin oxygenation and poisoning. The core competence in discipline such as evidence reasoning and model cognition has been developed.

关 键 词：物质结构与性质 证据推理与模型认知 血红素 模型 模型建构 空间结构 键长 

分 类 号：G633.8[文化科学—教育学]