植物乳杆菌协同单甘油月桂酸酯促进小鼠增重并改善血脂水平和炎症反应  

The Synergy of Lactobacillus plantarum and Glycerol Monolaurate Promotes Weight Gain,Improves Serum Lipids Level and Ameliorates Inflammation in Mice

作　　者：李杨[1,2] 张希 李阳[1] 冯凤琴[1] Li Yang;Zhang Xi;Li Yang;Feng Fengqin(College of Biosystems Engineering and Food Science,Zhejiang Key Laboratory for Agro-Food Processing,Zhejiang R&D Center for Food Technology and Equipment,Zhejiang University,Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs,Hangzhou 310058;School of Food Science and Engineering,Qingdao Agricultural University,Qingdao 266109;Yunnan University of Traditional Chinese Medicine,Kunming 650500)

机构地区：[1]浙江大学生物系统工程与食品科学学院,浙江省农产品加工技术研究重点实验室,浙江省食品加工技术与装备工程中心,农业农村部农产品产后处理重点实验室,杭州310058 [2]青岛农业大学食品科学与工程学院,青岛266109 [3]云南中医学院,昆明650500

出　　处：《中国食品学报》2020年第10期8-15,共8页Journal of Chinese Institute Of Food Science and Technology

基　　金：杭州市产学研合作项目(20161631E01)。

摘　　要：低剂量单甘油月桂酸酯(GML)的使用能引起血脂异常和低度炎症。为解决GML这一潜在的健康风险问题,研究了植物乳杆菌ZJUFT34(T34)对GML诱导的增重小鼠的血脂、胰岛素和细胞因子等方面的调节作用。以雄性C57BL/6小鼠为研究对象,分别饲喂基础饲料和含150 mg/kg GML的基础饲料,待GML诱导小鼠产生显著性增重后,灌胃T34处理3周,眼球采血后测定血清血脂水平、空腹葡萄糖和胰岛素水平以及细胞因子水平。结果表明:T34的使用,能维持GML引起的显著性增重,终体重比对照组增加了2.48 g(约9.3%),同时显著升高了高密度脂蛋白胆固醇/低密度脂蛋白胆固醇(HDL-C/LDL-C)的水平,改善了胰岛素抵抗,降低了促炎细胞因子白介素-6(IL-6)水平,并上调了抗炎细胞因子转化生长因子-β(TGF-β)的水平。T34和GML的配合使用,既能发挥GML促进生长的有利作用,又可以减轻GML的潜在危害,使增重小鼠维持健康状态。Low-dosage glycerol monolaurate(GML)administration was able to induce dyslipidemia and low grade inflammation in mice.Lactobacillus plantarum ZJUFT34(T34)was used to regulate the serum lipids,insulin and cytokines in overweight mice induced by GML,in order to address potential health risks associated with GML consumption.Male C57BL/6 mice were divided into two groups,fed with basic diet and basic diet containing 150 mg/kg GML,respectively.T34 was administered to mice after they exhibited significant body weight gain induced by GML.Blood samples were collected after a three-week T34 treatment.The levels of lipids,fasting glucose,insulin and cytokines in serum were determined.The results showed that the administration of T34 could maintain the significant body weight gain of the mice induced by GML and the final body weight was 2.48 g(approximately 9.3%)higher than the control group.T34 in combination with GML significantly elevated the ratio of high-density lipoprotein-cholesterol to low-density lipoprotein-cholesterol(HDL-C/LDL-C),ameliorated insulin resistance,decreased the pro-inflammatory cytokine interleukin-6(IL-6)level,and upregulated the anti-inflammatory cytokine transforming growth factor-β(TGF-β)level.T34 in combination with GML not only exert the beneficial effects of GML to promote mice growth,but also reduce the potential harm of GML and maintain health of mice.

关 键 词：植物乳杆菌 单甘油月桂酸酯 脂质调节 免疫调节 

分 类 号：TS201.4[轻工技术与工程—食品科学]