盐麸子对细胞氧化损伤及3T3-L1细胞分化的影响  

Effects of Rhus chinensis Mill.Fruits on Cellular Oxidative Damage and 3T3-L1 Differentiation

作　　者：蔡圣宝[1] 张璇 张成庭 胡小松[2] 易俊洁 Cai Shengbao;Zhang Xuan;Zhang Chengting;Hu Xiaosong;Yi Junjie(Faculty of Agriculture and Food,Kunming University of Science and Technology,Kunming 650500;College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083)

机构地区：[1]昆明理工大学农业与食品学院,昆明650500 [2]中国农业大学食品科学与营养工程学院,北京100083

出　　处：《中国食品学报》2020年第10期59-67,共9页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31660461)。

摘　　要：本研究利用体外细胞模型,在细胞层面上,探讨了盐麸子不同溶剂酚类物质提取物对细胞氧化损伤的保护作用,以及对3T3-L1前脂肪细胞分化的抑制活性。结果表明,盐麸子3种溶剂提取物及游离态多酚对H2O2诱导的HepG2细胞氧化损伤具有良好的保护作用,可显著降低细胞内的活性氧含量,减少细胞凋亡;同时可以显著抑制3T3-L1前脂肪细胞的分化。该研究结果为盐麸子的进一步应用和开发提供了一定的科学依据。In vitro cell models were used in this study to investigate the effect of different phenolics extracts of Chinese sumac(Rhus chinensis Mill.)fruits on cellular oxidative damage and 3T3-L1 differentiation at the cellular level.The results indicated that the three different solvent extracts and free phenolic fraction of Rhus chinensis Mill.fruits had good protection effects on the H2O2 induced oxidative damage of HepG2 cells and could significantly reduce the cellular ROS and apoptosis.In addition,those phenolic fractions could also significantly inhibit the differentiation of 3T3-L1 MBX preadipocytes.Results of the present work may supply scientific basis for further application of Rhus chinensis Mill.fruits.

关 键 词：盐麸子 细胞保护 酚类物质 氧化凋亡 分化抑制 

分 类 号：TS201.2[轻工技术与工程—食品科学]