几种市售婴幼儿配方奶粉中氯丙醇酯的定量检测及风险评估  

Quantitative detection and risk assessment of chloropropanol ester in several infant formula milk powder

作　　者：刘印平[1] 云鹏[1] 陈福尊[1] 王丽英[1] 路杨[1] 董彬[1] 冯静[1] 常凤启[1] LIU Yin-Ping;YUN Peng;CHEN Fu-Zun;WANG Li-Ying;LU Yang;DONG Bin;FENG Jing;CHANG Feng-Qi(Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang 050021,China)

机构地区：[1]河北省疾病预防控制中心,石家庄050021

出　　处：《食品安全质量检测学报》2020年第19期6867-6872,共6页Journal of Food Safety and Quality

摘　　要：目的对几种市售婴幼儿配方奶粉中2种氯丙醇酯进行定量检测并开展人体健康风险暴露评估。方法奶粉样品提取脂肪后,经碱水解,以硅藻土固相萃取法净化,样液经衍生后采用气相色谱/质谱联用法(gas chromatography/mass spectrometry, GC/MS)检测,以稳定性同位素内标法对3-氯-1,2-丙二醇酯和2-氯-1,3-丙二醇酯进行定量。结果奶粉中3-氯-1,2-丙二醇酯和2-氯-1,3-丙二醇酯的检出率分别为87.5%和62.5%,平均值分别为0.058 mg/kg和0.022 mg/kg。低月龄婴幼儿氯丙醇酯暴露风险较高,超出每日耐受摄入量(tolerable daily intake, TDI)[0.8μg/(kg·d)]。结论婴幼儿配方奶粉中氯丙醇酯污染问题应高度关注,尽快制定限量标准,以降低氯丙醇酯对婴幼儿造成的健康风险。Objective To quantitatively detect 2 chloropropanol esters in several commercially available infant formula and to conduct a human health risk exposure assessment. Methods The fat was extracted from the milk powder samples and purified by solid phase extraction from diatomite after the alkaline hydrolysis. Gas chromatography/mass spectrometry(GC/MS) was used to extract the fat from the samples, and the determination of 3-chlorine-1,2-propanediol esters and 2-chlorine-1,3-propanediol esters was performed using stable isotope internal chromatography. Results The detection rates of 3-chloro-1,2-propanediol ester and 2-chloro-1,3-propanediol ester in milk powder were 87.5% and 62.5%, respectively, with average values of 0.058 mg/kg and 0.022 mg/kg, respectively. The risk of exposure to chloropropane is high, exceeding the tolerable daily intake(tolerable daily intake, TDI) [0.8 μg/(kg·d)]. Conclusion The contamination of chloropropanol esters in infant formula milk powder should be paid close attention to, and the limit standard should be established as soon as possible to reduce the health risk of chloropropanol esters to infants and young children.

关 键 词：氯丙醇酯 婴幼儿配方奶粉 污染 暴露风险 

分 类 号：TS252.51[轻工技术与工程—农产品加工及贮藏工程]