Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases  

作　　者：Patrick Süβ Addison J.Lana Johannes C.M.Schlachetzki 

机构地区：[1]Department of Molecular Neurology,Friedrich-Alexander-University Erlangen-Nürnberg,University Hospital Erlangen,Erlangen,Germany [2]Department of Cellular and Molecular Medicine,University of California San Diego,La Jolla,CA,USA

出　　处：《Neural Regeneration Research》2021年第9期1711-1714,共4页中国神经再生研究（英文版）

摘　　要：The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma.

关 键 词：aging Alzheimer's disease INFLAMMATION innate immune system MICROGLIA NEURODEGENERATION Parkinson's disease 

分 类 号：R741[医药卫生—神经病学与精神病学]