The thermogenic circuit: Regulators of thermogenic competency and differentiation  

作　　者：Matthew D.Lynes Yu-Hua Tseng 

机构地区：[1]Section on Integrative Physiology and Metabolism,Joslin Diabetes Center,Harvard Medical School,Boston,MA,USA

出　　处：《Genes & Diseases》2015年第2期164-172,共9页基因与疾病（英文）

基　　金：This work was supported in part by National Institutes of Health(NIH)Grant(R01DK077097);Joslin Diabetes Center’s Diabetes Research Center(P30DK03836);a research grant from the American Diabetes Foundation(ADA 7-12-BS-191);by funding from the Harvard Stem Cell Institute(to Y-H.T).M.D.L was supported by NIH fellowships(T32DK007260 and F32DK102320).

摘　　要：In mammals,a thermogenic mechanism exists that increases heat production and consumes energy.Recent work has shed light on the cellular and physiological mechanisms that control this thermogenic circuit.Thermogenically active adipocytes,namely brown and closely related beige adipocytes,differentiate from progenitor cells that commit to the thermogenic lineage but can arise from different cellular origins.Thermogenic differentiation shares some features with general adipogenesis,highlighting the critical role that common transcription factors may play in progenitors with divergent fates.However,thermogenic differentiation is also discrete from the common adipogenic program and,excitingly,cells with distinct origins possess thermogenic competency that allows them to differentiate into thermogenically active mature adipocytes.An understanding of this thermogenic differentiation program and the factors that can activate it has led to the development of assays that are able to measure thermogenic activity both indirectly and directly.By combining these assays with appropriate cell models,novel therapeutic approaches to combat obesity and its related metabolic disorders by enhancing the thermogenic circuit can be developed.

关 键 词：ADIPOGENESIS Autologous transplants Brown adipose tissue Cell therapy UCP1 OBESITY PREADIPOCYTE THERMOGENESIS 

分 类 号：F42[经济管理—产业经济]