甜菊糖苷改善根皮素溶解性及体外释放的研究  

Improving of Solubilization and in Vitro Release Enhancement of Phloretin by Steviol Glycosides

作　　者：肖小年[1] 王凡[1] 周洁[1] 罗俊溢 李娟[2] 易醒[2] Xiao Xiaonian;Wang Fan;Zhou Jie;Luo Junyi;Li Juan;Yi Xing(Sino-German Joint Research Institute,Nanchang University,Nanchang 330047;Sino-German Food Engineering Center,Nanchang University,Nanchang 330047)

机构地区：[1]南昌大学中德联合研究院,南昌330047 [2]南昌大学中德食品工程中心,南昌330047

出　　处：《中国食品学报》2021年第3期11-21,共11页Journal of Chinese Institute Of Food Science and Technology

基　　金：国家自然科学基金项目(31760459,31960455)。

摘　　要：为了提高根皮素(PT)在水中的溶解性,利用甜菊糖苷(STE)可自组装形成胶束的特点,建立甜菊糖苷-根皮素胶束增溶体系(STE-PT MC)。通过体外模拟释放试验,对PT增溶前、后的释放度及释放动力学进行研究。结果表明,STE对PT产生良好的增溶效果,在最佳工艺条件下,1.03 g STE可将30 mg PT完全溶解于10 mL水中。STE-PT MC呈平均粒径为5.26 nm的圆球状外形,且STE和PT之间无化学反应发生。STE将PT在人工肠液和胃液中的释放度提高至原来的3~7倍,且增溶前、后的PT在两种介质中的释放动力学发生明显变化。本文建立的STE-PT MC增溶体系所用工艺简单,不添加其它成分,在食品工业上具有较好的实用性。In order to improve the aqueous solubility of phloretin(PT)in aqueous,steviol glycosides(STE),which can self-assemble to form micelles,was used to prepare steviol glycosides-phloretin micellar(STE-PT MC)complex.At the same time,in vitro release and kinetics of PT alone and PT from STE-PT MC were also investigated.The results showed that STE exhibited significant solubility enhancement on PT and 1.03 g of STE can completely dissolve 30 mg of PT in 10 mL of water under the optimum preparation conditions.STE-PT MC was spherical with an average droplet size of 5.26 nm and without any chemical reaction taken place between STE and PT.In vitro release amounts of PT from STE-PT MC in simulate intestinal fluid and stimulate gastric fluid were 3 to 7 times of that of PT alone.In addition,in vitro release kinetics of PT alone and PT from STE-PT MC were significantly different.The STE-PT MC without any other ingredients addition has a simple preparation process and good practicability in food industry.

关 键 词：根皮素 甜菊糖苷 胶束 溶解度 体外释放 

分 类 号：TS264.9[轻工技术与工程—发酵工程]