Multiple hurdle mechanism and blood-brain barrier in epilepsy:glucocorticoid receptor-heat shock proteins on drug regulation  

作　　者：Aneesha Achar Chaitali Ghosh 

机构地区：[1]Cerebrovascular Research,Department of Biomedical Engineering,Lerner Research Institute,Cleveland Clinic,Cleveland,OH,USA [2]Department of Biomedical Engineering and Molecular Medicine,Cleveland Clinic Lerner College of Medicine of Case Western Reserve University,Cleveland,OH,USA

出　　处：《Neural Regeneration Research》2021年第12期2427-2428,共2页中国神经再生研究（英文版）

基　　金：The present work is supported in part by the National Institute of Neurological Disorders and Stroke/National Institutes of Health grants R01NS095825(to CG).

摘　　要：Epilepsy is a complex neurologic condition which affects over 50 million people worldwide.Pharmacotherapy,primarily involving the use of anti-seizure drugs(ASDs),is an essential part of controlling seizures.However,nearly 30%of patients develop drug-resistant epilepsy,clinically defined as the persistence of seizure following trials of two ASDs(Kwan et al.,2010).Although several hypotheses have been proposed to explain this phenomenon,the mechanism of drug-resistant epilepsy still remains unclear.

关 键 词：EPILEPSY DRUG DRUGS 

分 类 号：R742.1[医药卫生—神经病学与精神病学]