Dysregulation of autophagy and mitochondrial function in Parkinson’s disease  

作　　者：Bao Wang Neeta Abraham Guodong Gao Qian Yang 

机构地区：[1]Department of Neurosurgery,Tangdu Hospital,The Fourth Military Medical University,No.569 Xinsi Road,Baqiao District,Xi’an 710038,Shaanxi Province,China [2]Department of Neurology,Beth Isreal Deaconess Medical Center,Harvard Medical School,330 Brookline Ave,Boston 02215,MA,USA

出　　处：《Translational Neurodegeneration》2016年第1期152-160,共9页转化神经变性病（英文）

基　　金：The works were supported by National Natural Science Foundation of China(Grant No.31371400)(Q.Y)and(Grant No.31671060)(Q.Y).

摘　　要：Parkinson’s disease(PD)is the second most common neurodegenerative disease.Increasing evidence supports that dysregulation of autophagy and mitochondrial function are closely related with PD pathogenesis.In this review,we briefly summarized autophagy pathway,which consists of macroautophagy,microautophagy and chaperone-mediated autophagy(CMA).Then,we discussed the involvement of mitochondrial dysfunction in PD pathogenesis.We specifically reviewed the recent developments in the relationship among several PD related genes,autophagy and mitochondrial dysfunction,followed by the therapeutic implications of these pathways.In conclusion,we propose that autophagy activity and mitochondrial homeostasis are of high importance in the pathogenesis of PD.Better understanding of these pathways can shed light on the novel therapeutic methods for PD prevention and amelioration.

关 键 词：Parkinson’s disease AUTOPHAGY MACROAUTOPHAGY MITOPHAGY Chaperone-mediated autophagy Mitochondria α-synuclein PINK/Parkin LRRK2 DJ-1 

分 类 号：R74[医药卫生—神经病学与精神病学]