Thymic epithelial cell development and differentiation: cellular and molecular regulation  

作　　者：Lina Sun Haiying Luo Hongran Li Yong Zhao 

机构地区：[1]State Key Laboratory of Biomembrane and Membrane Biotechnology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Protein & Cell》2013年第5期342-355,共14页蛋白质与细胞（英文版）

基　　金：supported by grants from the National Basic Research Program(973 Program)(Nos.2010CB945301,and 2011CB710903,Y.Z.);National Natural Science Foundation of China(Grant Nos.C81072396 and U0832003,Y.Z.).

摘　　要：Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.

关 键 词：THYMUS thymic epithelial cells AIRE Foxn1 TNFR NF-ΚB FGFS 

分 类 号：R73[医药卫生—肿瘤]