supported by the National Natural Science Foundation of China(Nos.81274172,81473267,81973637 and 82373933);The National Traditional Chinese Medicine Inheritance and Innovation“Hundreds and Thousands”Talent Project:Young Qihuang Scholar Support Project of the State Administration of Traditional Chinese Medicine in 2020(China).
Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing...
financially supported by the Science and Technology Commission of Shanghai Municipality(21ZR1427200).
Carassius auratus herpesvirus(CaHV)is a pathogen isolated from crucian carp(Carassius auratus)associated with high mortality.A diagnosis method that can detect the virus at an early stage,specifically and accurately,i...
National Key R&D Program of China,Grant/Award Number:2022YFB3808100;National Natural Science Foundation of China,Grant/Award Numbers:32271442,52130301,82072048;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2022B1515020025;Science and Technology Program of Guangzhou,China,Grant/Award Number:202103030004;Fundamental Research Funds for the Central Universities,Grant/Award Number:2022ZYGXZR102。
Tumor necrosis factor receptors(TNFRs)are promising targets for cancer therapy.However,activating their downstream signaling requires cross-linking of TNFRs.Herein,to devise strong agonists of TNFRs,ligands targeting ...
Supported by Hungarian National Research,Development and Innovation Fund Projects,No.GINOP-2.3.3-15-2016-00006;Hungarian NKFIH Fund Project,No.FK131789(to Bódi N);János Bolyai Research Scholarship of the Hungarian Academy of Sciences(to Bódi N);ÚNKP-21-5-New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund(to Bódi N);Gedeon Richter Plc Centenary Foundation(to Bódi N).
BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 diabetes.Tumor necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a...