Progranulin:A promising biomarker and therapeutic target for fibrotic diseases  

作　　者：Fan Yang Ming-Han Cheng Hai-Feng Pan Jian Gao 

机构地区：[1]Pediatric Translational Medicine Institute,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200000,China [2]Department of Ophthalmology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China [3]Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230022,China [4]Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei 230022,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3312-3326,共15页药学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81274172,81473267,81973637 and 82373933);The National Traditional Chinese Medicine Inheritance and Innovation“Hundreds and Thousands”Talent Project:Young Qihuang Scholar Support Project of the State Administration of Traditional Chinese Medicine in 2020(China).

摘　　要：Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory response.PGRN was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF receptors.Notably,excessive tissue repair in the development of inflammation causes tissue fibrosis.Previous investigations have indicated the significance of PGRN in regulating inflammatory responses.Recently,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and skin.This paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in fibrosis.This is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular signaling.Finally,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关 键 词：Progranulin Fibrotic disease FIBROSIS INFLAMMATION BIOMARKER Therapeutic target PGRN/TNFR interaction Signaling pathway 

分 类 号：R749.16[医药卫生—神经病学与精神病学]