Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy,oxidative therapy and immunotherapy for melanoma treatment  

作　　者：Qi Zhang Xiangdong Guo Yingnan Cheng Lalit Chudal Nil Kanatha Pandey Jieyou Zhang Lun Ma Qing Xi Guangze Yang Ying Chen Xin Ran Chengzhi Wang Jingyi Zhao Yan Li Li Liu Zhi Yao Wei Chen Yuping Ran Rongxin Zhang 

机构地区：[1]Department of Immunology and Research Center of Basic Medical Sciences,Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China,Tianjin Key Laboratory of Cellular and Molecular Immunology,Tianjin Medical University,300070 Tianjin,China [2]Institute of Integrative Medicines for Acute Abdominal Diseases,Tianjin Nankai Hospital,300100 Tianjin,China [3]Department of Physics,The University of Texas at Arlington,Arlington,TX 76019-0059,USA [4]Guangdong Province Key Laboratory for Biotechnology Drug Candidates,Institute of Basic Medical Sciences,School of Life Sciences and Biopharmaceutics,Guangdong Pharmaceutical University,Guangzhou,China [5]Department of Dermatovenereology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China [6]Department of Radiology,The University of Texas Southwestern Medical Center,Dallas,TX,USA

出　　处：《Signal Transduction and Targeted Therapy》2020年第1期1852-1854,共3页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China through No.81872320,31600730,81602496,and 81272317;the Innovation and University Promotion Project of Guangdong Pharmaceutical University through No.2017KCXTD020.W.C.

摘　　要：Dear Editor,Melanoma,squamous cell carcinoma(SCC),and basal cell carcinoma(BCC)are three major types of skin cancer.Among them,melanoma is the most severe form and accounts for~4%of all newly diagnosed cancers annually in the United States.It is estimated that approximately 9500 people are diagnosed with skin cancer every day,and more than 1 million Americans are living with melanoma.Melanoma treatment is still a major challenge in the clinic.Photodynamic therapy(PDT)is composed of targeted ablation and immune activation,is less invasive than other therapies and has been widely used in the treatment of various cancers.

关 键 词：MELANOMA TREATMENT RADIOTHERAPY 

分 类 号：R739.5[医药卫生—肿瘤]