Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis  

作　　者：Qian-Qian Wei Yan-Bing Hou Ling-Yu Zhang Ru-Wei Ou Bei Cao Yong-Ping Chen Hui-Fang Shang 

机构地区：[1]Department of Neurology,Laboratory of Neurodegenerative Disorders,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China

出　　处：《Neural Regeneration Research》2022年第4期875-880,共6页中国神经再生研究（英文版）

基　　金：supported by the Science and Technology Bureau Fund of Sichuan Province of China,No.2020YFS0220;the China Postdoctoral Science Foundation,No.2019M653427;Postdoctoral Research Project,West China Hospital,Sichuan University of China,No.2019HXBH029;Health Commission of Sichuan Province of China,No.20PJ038(all to QQW)。

摘　　要：The neutrophil-to-lymphocyte ratio(NLR)is considered a robust prognostic biomarker for predicting patient survival outcomes in many diseases.However,it remains unclear whether it can be used as a biomarker for amyotrophic lateral sclerosis(ALS).To correlate NLR with disease progression and survival in sporadic ALS,1030 patients with ALS between January 2012 and December 2018 were included in this study.These patients were assigned into three groups according to their NLR values:Group 1(NLR<2,n=544[52.8%]),Group 2(NLR=2–3,n=314[30.5%]),and Group 3(NLR>3,n=172[16.7%]).All patients were followed up until April 2020.Patients in Group 3 had a significantly older onset age,a lower score on the Revised ALS Functional Rating Scale,and rapidly progressing disease conditions.Furthermore,faster disease progression rates were associated with higher NLR values(odds ratio=1.211,95%confidence interval[CI]:1.090–1.346,P<0.001)after adjusting for other risk factors.Compared with Groups 1 and 2,the survival time in Group 3 was significantly shorter(log-rank P=0.002).The NLR value was considered an independent parameter for the prediction of survival in ALS patients after normalizing for all other potential parameters(hazard ratio[HR]=1.079,95%CI:1.016–1.146,P=0.014).The effects on ALS survival remained significant when adjusted for treatment(HR=1.074,95%CI:1.012–1.141,P_(trend)=0.019)or when considering the stratified NLR value(HR=1.115,95%CI:1.009–1.232,P_(trend)=0.033).Thus,the NLR may help to predict the rate of disease progression and survival in patients with sporadic ALS.The study was approved by the Institutional Ethics Committee of West China Hospital of Sichuan University,China(approval No.2015(236))on December 23,2015.

关 键 词：amyotrophic lateral sclerosis Cox analysis INFLAMMATION LYMPHOCYTES MONOCYTES NEUTROPHILS PROGNOSIS survival rate 

分 类 号：R744.8[医药卫生—神经病学与精神病学]