O-glycosylation in liver cancer:Clinical associations and potential mechanisms  

作　　者：Kung-Hao Liang Chau-Ting Yeh 

机构地区：[1]Liver Research Center,Chang Gung Memorial Hospital,Taoyuan,Taipei,China [2]Medical Research Department,Taipei Veterans General Hospital,Taipei,China [3]Molecular Medicine Research Center,Chang Gung University,Taoyuan,Taipei,China

出　　处：《Liver Research》2017年第4期193-196,共4页肝脏研究（英文）

基　　金：This project was supported by Chang Gung Medical Foundation(CMRPG1B0571,CIRPG3B0032,CMRPG3F1601).

摘　　要：Liver cancer can be an aggressive disease,and is highly prevalent in Asia and Africa.However,its currently approved therapeutic strategies are far from satisfactory.Recent progress in genomic,proteomic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical outcomes.Many biomarkers are related to O-glycosylation of glycoproteins,which belong to an important but less-explored field of liver cancer biology.Here,we review these clinical studies and discuss potential underlying mechanisms.

关 键 词：O-GLYCOSYLATION Post-translational modification GLYCOBIOLOGY Biomarkers Hepatocellular carcinoma(HCC) GLYCOSYLTRANSFERASE 

分 类 号：R73[医药卫生—肿瘤]