supported by the National Natural Science Foundation of China(grant No.81972041);the Beijing Natural Science Foundation(grant No.7172112)。
Glycans,either alone or in complex with glycan-binding proteins,are essential structures that can regulate cell biology by mediating protein stability or receptor dimerization under physiological and pathological cond...
NIH R01CA175495 and R01CA262132;the Department of Defense(PC210331 and BC190403);the Price Family Foundation.M.C.P.is supported by NIH 5TL1TR002557.A.T.M.is supported by Scandinavia/Borge.
The B7/CD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various diseases.Recent basic and clinical studies have revealed novel biology of the ...
supported by NIH training fellowships 5T32HD08798 and 5K12HL141956 to RS and NIH research grant R01AI145310 to VN.
The primary defect in cystic fibrosis(CF)is abnormal chloride and bicarbonate transport in the CF transmembrane conductance regulator epithelial ion channel.The apical surface of the respiratory tract is lined by an a...
As one of the four major classes of biomolecules(carbo-hydrate,protein,nuclcotide,and lipid),carbohydrates are themost prominent features of the cell's exterior.Carbohydratesand their conjugates(glycoproteins.glycolip...
This project was supported by Chang Gung Medical Foundation(CMRPG1B0571,CIRPG3B0032,CMRPG3F1601).
Liver cancer can be an aggressive disease,and is highly prevalent in Asia and Africa.However,its currently approved therapeutic strategies are far from satisfactory.Recent progress in genomic,proteomic and glycomic pr...