Functional roles of gut bacteria imbalance in cholangiopathies  

作　　者：Keisaku Sato Fanyin Meng Giammarco Fava Shannon Glaser Gianfranco Alpini 

机构地区：[1]Division of Research,Central Texas Veterans Health Care System,Temple,TX,USA [2]Baylor Scott&White Digestive Disease Research Center,Baylor Scott&White Health Care,Temple,TX,USA [3]Department of Medical Physiology,Texas A&M University College of Medicine,Temple,TX,USA [4]Ospedali Riuniti di Ancona,Ancona,Italy

出　　处：《Liver Research》2019年第1期40-45,共6页肝脏研究（英文）

基　　金：This work was supported in part by the Dr.Nicholas C.High-tower Centennial Chair of Gastroenterology from Scott&White,a Veterans Health Administration Research Career Scientist award(IK6BX004601);a VA Merit award to Dr.G.Alpini(5I01BX000574);a VA Merit Award(1I01BX001724)to Dr.F.Meng from the United States Department of Veterans Affairs Biomedical Laboratory Research;the USA National Institutes of Health(NIH)grants DK110035,DK054811,DK062975,DK115184,AA025997 and AA025157 to Drs.G.Alpini,F.Meng and S.Glaser.

摘　　要：Cholangiopathies are caused by bile duct damage or inflammation followed by cholestasis leading to liver fibrosis.Bile duct epithelial cells,cholangiocytes,are a primary target for cholangiopathies.Ductular reaction is often observed in cholangiopathies and the proliferation of cholangiocytes is associated with ductular reaction and liver fibrogenesis.Accumulating evidence suggests that patients with chol-angiopathies have different gut bacterial profiles from healthy individuals,indicating the association between gut microbiota and cholangiopathies.Bile acids are produced by hepatocytes and modified by gut bacteria.Bile acids regulate cholangiocyte proliferation but effects vary depending on the type of bile acids.Recent studies suggest that therapies targeting gut bacteria,such as antibiotics administration and gut bacteria depletion or therapies using gut bacteria-associated bile acids,such as ursodeoxycholic acid(UDCA)administration,may be useful for treatments of cholangiopathies,although data are contro-versial depending on animal models or cohorts.This review summarizes current understandings of functional roles of gut bacterial imbalance and strategies for treatments of cholangiopathies targeting gut bacteria.

关 键 词：Cholangiopathies Bile acids Gut bacteria CHOLANGIOCYTES CHOLESTASIS INFLAMMATION 

分 类 号：R57[医药卫生—消化系统]