Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI  

作　　者：Rodolfo G.Gatto Carina Weissmann 

机构地区：[1]Department of Bioengineering,the University of Illinois at Chicago,Chicago,IL,USA [2]Instituto de Fisiología Biología Molecular y Neurociencias-IFIBYNECONICET,Universidad de Buenos Aires,Buenos Aires,Argentina

出　　处：《Neural Regeneration Research》2022年第5期983-986,共4页中国神经再生研究（英文版）

基　　金：supported in part by the High Magnetic Field Laboratory(NHMFL)and Advanced Magnetic Resonance Imaging and Spectroscopy(AMRIS)under Magnetic Laboratory Visiting Scientist Program Award,No.VSP#327(to RG)。

摘　　要：During the last decades,advances in the understanding of genetic,cellular,and microstructural alterations associated to Huntington's disease(HD)have improved the understanding of this progressive and fatal illness.However,events related to early neuropathological events,neuroinflammation,deterioration of neuronal connectivity and compensatory mechanisms still remain vastly unknown.Ultra-high field diffusion MRI(UHFD-MRI)techniques can contribute to a more comprehensive analysis of the early microstructural changes observed in HD.In addition,it is possible to evaluate if early imaging microstructural parameters might be linked to histological biomarkers.Moreover,qualitative studies analyzing histological complexity in brain areas susceptible to neurodegeneration could provide information on inflammatory events,compensatory increase of neuroconnectivity and mechanisms of brain repair and regeneration.The application of ultra-high field diffusion-MRI technology in animal models,particularly the R6/1 mice(a common preclinical mammalian model of HD),provide the opportunity to analyze alterations in a physiologically intact model of the disease.Although some disparities in volumetric changes across different brain structures between preclinical and clinical models has been documented,further application of different diffusion MRI techniques used in combination like diffusion tensor imaging,and neurite orientation dispersion and density imaging have proved effective in characterizing early parameters associated to alteration in water diffusion exchange within intracellular and extracellular compartments in brain white and grey matter.Thus,the combination of diffusion MRI imaging techniques and more complex neuropathological analysis could accelerate the discovery of new imaging biomarkers and the early diagnosis and neuromonitoring of patients affected with HD.

关 键 词：brain repair diffusion tensor imaging Huntington's disease neurite orientation dispersion and density imaging neuroconnectivity NEUROINFLAMMATION NEUROPLASTICITY NEUROREGENERATION R6/1 mice ultra-high field diffusion MRI 

分 类 号：R742.2[医药卫生—神经病学与精神病学]