A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows  

作　　者：Madison N.Myers Maya Zachut Joseph Tam G.Andres Contreras 

机构地区：[1]Department of Large Animal Clinical Sciences,College of Veterinary Medicine,Michigan State University,East Lansing,MI 48824,USA [2]Department of Ruminant Science,Institute of Animal Sciences,Agricultural Research Organization/Volcani Center,7505101 Rishon LeZion,Israel [3]Obesity and Metabolism Laboratory,The Institute for Drug Research,School of Pharmacy,Faculty of Medicine,The Hebrew University of Jerusalem,9112001 Jerusalem,Israel

出　　处：《Journal of Animal Science and Biotechnology》2021年第3期995-1007,共13页畜牧与生物技术杂志（英文版）

基　　金：This project was funded by the US-Israel Binational Agricultural Research and Development Fund(Grant IS-5167-19);MNS was supported in part by the USDA National Institute for Food and Agriculture(Washington,DC,USA)competitive project 2019-67015-29443.

摘　　要：To sustain the nutrient demands of rapid fetal growth,parturition,and milk synthesis,periparturient dairy cows mobilize adipose tissue fatty acid stores through lipolysis.This process induces an inflammatory response within AT that is resolved as lactation progresses;however,excessive and protracted lipolysis compounds the risk for metabolic and inflammatory diseases.The suppression of lipolytic action and inflammation,along with amplification of adipogenesis and lipogenesis,serve as prospective therapeutic targets for improving the health of periparturient dairy cows.Generally,the activation of cannabinoid receptors by endocannabinoids enhances adipogenesis and lipogenesis,suppresses lipolysis,and increases appetite in mammals.These biological effects of activating the endocannabinoid system open the possibility of harnessing the endocannabinoid system through nutritional intervention in dairy herds as a potential tool to improve dairy cows’health,although much is still to be revealed in this context.This review summarizes the current knowledge surrounding the components of the endocannabinoid system,elaborates on the metabolic effects of its activation,and explores the potential to modulate its activity in periparturient dairy cows.

关 键 词：ADIPOGENESIS Adipose tissue Dairy cow health ENDOCANNABINOIDS Endocannabinoid system LIPOGENESIS LIPOLYSIS 

分 类 号：S823.5[农业科学—畜牧学]