虾青素化学和生物合成研究进展  

Research Progress on Chemical and Biological Synthesis of Astaxanthin

作　　者：陈丹 汪锋[1] 蒋珊 刘鹏阳 朱航志 李翔宇 万霞[2,4,5] CHEN Dan;WANG Feng;JIANG Shan;LIU Pengyang;ZHU Hangzhi;LI Xiangyu;WAN Xia(Wuhan Institute of Technology,School of Chemical Engineering and Pharmacy,Wuhan 430205,China;Oil Coops Research Institute of Chinese Academy of Agricultural Sciences,Wuhan 430062,China;Cabio Biotechnology Co.,Ltd.,Wuhan 430073,China;Laboratory of Oil Crops Biology and Genetics and Breeding,Ministry of Agriculture and Rural Affairs,Wuhan 430062,China;Laboratory of Oil Processing,Ministry of Agriculture and Rural Affairs,Wuhan 430062,China)

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430205 [2]中国农业科学院油料作物研究所,湖北武汉430062 [3]嘉必优生物技术(武汉)股份有限公司,湖北武汉430073 [4]农业农村部油料作物生物学与遗传育种重点实验室,湖北武汉430062 [5]农业农村部油料加工重点实验室,湖北武汉430062

出　　处：《食品工业科技》2021年第21期445-453,共9页Science and Technology of Food Industry

基　　金：中国农科院基础前沿培育项目(Y2020XK25);中国农科院创新工程(CAAS-ASTIP-2016-OCRI);“十三五”国家重点研发计划重点专项(2016YFD0501209)。

摘　　要：虾青素是一种重要的次级类胡萝卜素,具有极强的抗氧化性能,在食品、化工、医疗、水产养殖等方面具有广泛应用。虾青素的合成方法有化学合成及生物合成,化学合成是目前商业化虾青素来源,但生物合成的虾青素更安全,在食品、保健品行业更受欢迎。研究发现生物体内虾青素的代谢合成与油脂代谢路径间存在着一定的联系。本文综述了虾青素的化学合成法和生物合成法,重点综述了微生物中参与虾青素生物合成的关键基因及其代谢调控网络。概述了利用随机诱变、代谢工程、酶工程等手段提高细菌、酵母、海洋真核微生物等虾青素合成积累的研究进展。本文可为虾青素的高效合成研究提供理论指导。Astaxanthin is an important secondary carotenoid with extremely strong antioxidative properties and is widely used in food,chemicals,pharmaceuticals,aquacultures and so on.The synthetic methods of astaxanthin include chemical synthesis and biosynthesis.Chemical synthesis of astaxanthin is the source of commercial astaxanthin,while biosynthesis of astaxanthin is safer and more popular in food and health products industries.This review summaries chemical synthetic and biosynthetic pathway of astaxanthin,with emphasizing on the biosynthetic pathways of astaxanthin,key genes involved in biosynthetic and metabolic network of astaxnathin in microorganisms and plants.The research progress of using random mutagenesis,metabolic engineering,enzyme engineering and other methods to improve the synthesis and accumulation of astaxanthin in bacteria,yeast,and marine eukaryotic microorganisms is summarized.This article can provide theoretical guidance for the research on the efficient synthesis of astaxanthin.

关 键 词：虾青素 化学合成 生物合成 代谢路径 

分 类 号：TS209[轻工技术与工程—食品科学]